Main description:

This book describes the state of the art in the field of bioanalytical nano- and microsystems with optical functionality. In 12 chapters distinguished scientists and leaders in their respective fields show how various optical technologies have been miniaturized and integrated over the last few decades in order to be combined with nano- and microsystems for applications in the life sciences. The main detection and characterization technologies are introduced, and examples of the superiority of these integrated approaches compared to traditional ones are provided. Examples from e.g. the fields of optical waveguides, integrated interferometers, surface plasmon resonance or Raman spectroscopy are introduced and discussed, and it is shown how these approaches have led to novel functionalities and thereby novel applications.

Contents:

Part I Photometry, Color Sensors and Fluorescence Labels
Colour sensors and their applications
(Poenar Daniel Puiu)
Addressing of concentration spaces for bioscreenings by micro segmented flow with microphotometric and microfluorimetric detection
(J. Michael Koehler, Anette Funfak, Jialan Cao, Dana Kursten, Steffen Schneider and P. Mike Gunther)
Nanotechnology for diagnostic and sensing: soft and advanced imaging/sensing approaches to analyze biomolecules.
(A. Aloisi and Ross Rinaldi)

Part II Optical Waveguides
Integrated Optical Microsystems for Interferometric Analytics
(G.G. Bentini and Chiarini)
Label-free photonic chips for biosensing
(Raphael K. Kribich)

Part III Surface Plasmon Resonance
Surface Plasmon Resonance Bioanalytical platform to appraise the interaction between antimicrobial peptides and lipid membranes
(Mihaela Gheorghiu, Sorin David, Andreea Olaru, Cristina Polonschii, Eugen Gheorghiu)
Biological applications of Surface Plasmon Resonance Imaging.
(L. Leroy, E. Maillart, T. Livache)

Part IV Raman Spectroscopy
Lab-on-a-Chip Surface Enhanced Raman Spectroscopy (LOC-SERS)
(A. Marz, P. Roesch, T. Henkel, D. Malsch, J. Popp)
Microfluidic Raman spectroscopy for biochemical
sensing and analysis
(Praveen C. Ashok and Kishan Dholakia)

Part V Optical Characterization and Manipulation in Bioreactors
Polymeric microfluidic devices for high performance optical imaging and detection methods in bioanalytics
(Holger Becker, Claudia Gartner)
Chip Systems for analysis of nucleic acids with integrated amplification and detection
(Sandra Julich, Mark Kielpinski, Matthias Urban, Thomas Henkel, Marko Riedel, Sabine Werres, Stefan Wagner, Robert Moeller, Wolfgang Fritzsche)
Optofluidic microsystems for application in biotechnology and life sciences
(S. Sinzinger, B. P. Cahill, J. Metze, M. Hoffmann)