Main description:

Diabetes Mellitus, a syndrome of disordered metabolism, characterised by abnormal elevation in blood glucose level, has become a life-threatening condition for many people. Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin. This title begins with an introductory chapter on symptoms, complications and therapy for Diabetes Mellitus. Subsequent chapters cover the various routes for administering insulin; the challenges and strategies of oral delivery; experimental techniques in the development of an oral insulin carrier; lipids; inorganic nanoparticles and polymers in oral insulin delivery; and a summary and presentation of future perspectives on oral delivery of insulin.

Contents:

List of figures and tables

Figures
Tables

About the authors
1: Diabetes mellitus - an overview

Abstract
1.1 Diabetes mellitus - an introduction
1.2 Glucose homeostasis
1.3 Types of diabetes
1.4 Symptoms of diabetes
1.5 Complications of diabetes
1.6 Diagnosis of diabetes mellitus
1.7 Therapy for diabetes
1.8 Non-insulin treatment options of type 1 diabetes
1.9 Treatment options of type 2 diabetes
1.10 Conclusion

2: Routes of administration of insulin

Abstract
2.1 Current approach for the delivery of insulin
2.2 Routes of administration of insulin
2.3 Conclusion

3: Oral insulin delivery - challenges and strategies

Abstract
3.1 Oral delivery of insulin
3.2 Barriers to oral delivery of insulin
3.3 Strategies and alternatives to improve oral insulin delivery
3.4 Conclusion

4: Experimental techniques involved in the development of oral insulin carriers

Abstract
4.1 Introduction
4.2 Polymeric nanoparticles
4.3 Physicochemical characterization of nanoparticles
4.4 Biological evaluation
4.5 In vitro method for assessing drug permeability
4.6 In vivo study of oral insulin
4.7 Biodistribution studies
4.8 Conclusion

5: Lipids and inorganic nanoparticles in oral insulin delivery

Abstract
5.1 Lipid-based systems for oral delivery of insulin
5.2 Liposomes
5.3 Solid lipid nanoparticles
5.4 Nanostructured lipid carriers
5.5 Niosomes
5.6 Archaeosomes
5.7 Cubic nanoparticles (cubosomes)
5.8 Aquasomes
5.9 Inorganic nanoparticles as carriers for oral insulin delivery
5.10 Conclusion

6: Polymers in oral insulin delivery

Abstract
6.1 Introduction
6.2 Characteristics of an ideal oral insulin carrier
6.3 Polymers in oral insulin delivery
6.4 Natural polymers
6.5 Synthetic polymers
6.6 Conclusion

7: Summary and future perspectives for oral insulin delivery

Abstract
7.1 Introduction
7.2 Technologies developed for clinical applications of oral insulin delivery
7.3 Conclusions and future perspectives

Index