Main description:

A first "pathobiochemist's view" giving only a short clinical/medical background but a condensed overview about biochemical pathways closely related to several facets of the Metabolic Syndrome.

Feature:

Condensed pathobiochemist's view on the major facets of the Metabolic Syndrome
Focus on specific signalling pathways and molecular mechanisms that are involved in the Metabolic Syndrome
Connection between subclinical inflammation, insulin resistance and cancer is highlighted

Back cover:

The concept of pathogenesis of the Metabolic Syndrome, a constellation of disease states and conditions including insulin resistance, diabetes mellitus type 2, obesity, dysregulation of lipid and lipoprotein metabolism, vascular dysfunction, hypertension, and accelerated atherogenesis is becoming increasingly important not only for physicians but also for other life science disciplines. This book will be a "pathobiochemist's view" on the Metabolic Syndrome based on a series of lectures for chemists, food chemists, biochemists, biotechnologists, and biologists. A short clinical background and a condensed overview about biochemical pathways are given, closely related to various facets of the Metabolic Syndrome in context. Specific emphasis has been placed on intracellular signaling cascades associated with insulin resistance, adipose tissue inflammation and hypoxia, non-alcoholic liver inflammation, disturbed lipid homeostasis, mitochondrial dysfunction, and endothelial dysfunction. The putative association with cancerogenesis and new findings on the genetics of the Metabolic Syndrome are discussed and the development of dedicated animal models are included.

Contents:

Preface

Chapter 1 Definition of the Metabolic Syndrome

Chapter 2 Insulin signaling and insulin resistance

Chapter 3 Adipose tissue inflammation and hypoxia

Chapter 4 Mitochondrial dysfunction

Chapter 5 Nonalcoholic liver inflammation

Chapter 6 Dysregulation of apolipoprotein metabolism and disturbed lipid homeostasis

Chapter 7 Endothelial dysfunction

Chapter 8 Genetics of the Metabolic Syndrome

Chapter 9 Metabolic Syndrome and Ovarian Polycystosis

Chapter 10 Metabolic Syndrome and Cancer

Chapter 11 Animal Models of the Metabolic Syndrome

Bibliography