Main description:

The book covers all aspects of peri-operative anesthetic management of liver transplant patients. It provides a comprehensive coverage of the relevant history, surgeons', hepatologists', intensivists' and pediatricians' perspective of the disease, its pathogenesis, clinical presentation and indication for transplant. It discusses the practical aspects like fluid management and use of vasopressors. The book is divided into sections for a better and comprehensive delivery of information. Individual sections provide up to date information on the pre-operative issues and optimisation, intra-operative care and management and post-operative critical care issues and management of all transplant patients with special emphasis on recent advances. Separate sections cover ICU care of these patients in great detail and anesthetic management of pediatric liver transplant. The book includes anesthetic techniques involved in conducting multiorgan transplant. It discusses clinical approach to a patient with acute liver failure, brain death criteria and laws and organ donor management. It also presents newer techniques and methodologies adopted in the field of liver transplant. It includes ample illustrations, flowcharts, key points in each chapter, figures and photographs. The book contains chapters focusing on post-transplant patients presenting for non-transplant surgery.

The book fills the gap in the literature for a comprehensive guide for the anesthetist performing or pursuing liver transplant, students/trainees/examinees who have a keen interest in this field and doctors dealing with such patients in critical care, donor management, pursuing general anesthesia. It is also helpful for hepatologists, intensivists and surgeons associated with liver transplant.

Contents:

1. History of liver transplantation - Indian perspective2. Physiological role of liver & interpreting liver function tests3. Pathophysiology of chronic liver disease4. Pharmacokinetics & Pharmacodynamics of drugs in liver disease5. Surgical anatomy of the liver6. Non-transplant surgery for pre-transplant cirrhotic7. Viral markers and their relevance in liver disease and transplantation8. Indications and contraindications for liver transplantation9. Disease Severity Scoring System in Chronic Liver Disease10. Pre-operative assessment and optimization of liver transplant patients - Ascites, Hydrothorax11. Pre-operative assessment and optimization of liver transplant patients - Cardiac issues in liver disease12. Pre-operative assessment and optimization of liver transplant patients - Renal issues in liver disease13. Pre-operative assessment and optimization - of liver transplant patients - Pulmonary issues in liver disease14. Pre-operative assessment and optimization of liver transplant patients - Coagulation issues15. Pre-operative assessment and optimization - of liver transplant patients - Nutrition16. Intra-operative management of transplant recipient - An overview17. Intra-operative monitoring - Hemodynamic monitoring in liver transplant surgery18. Intra-operative monitoring - Coagulation monitoring in liver transplant surgery19. Ischemia reperfusion injury20. Intra-operative fluids in liver transplant surgery21. Role of vasopressors in liver transplant surgery22. Minimizing blood loss in recipient surgery - Antifibrinolytics/ Cell saver/ VVB/ Pringle and Surgical techniques23. Venovenous bypass (VVB) in liver transplantation24. Role of ECMO in Liver Transplant25. Intra-operative complications and management - Air embolism, Surgical/ Medical haemorrhage, GI bleed, Intra-operative Oliguria, Refractory hypotension, Arrhythmias26. Peri-operative assessment & management of live donor for donor hepatectomy27. Brain Death and Organ Donation28. Management of deceased donor for organ donation29. Critical care management of acute liver failure30. Assessment for transplanting acute liver failure patient31. Bridging therapies in Acute Liver Failure (Hemodialysis and plasma exchange, Blood purification, Liver assist devices)32. Anesthetic management of acute liver failure for liver transplant33. Anesthetic issue in the management of pediatic liver transplant34. Challenges in pediatric liver transplant35. Critical care management of pediatric liver transplant recipient36. Combined liver kidney transplant37. ABOI liver transplantation - Peri-operative consideration38. Non-transplant surgery for post-transplant patient39. Acute on chronic liver failure - An update40. Anesthesia for interventional radiology in CLD & transplanted patient41. Early post-operative care of transplant recipient42. Assessment of early graft function and management of early graft failure43. Post-operative renal dysfunction in recipient44. Immunosuppression45. Fast tracking in liver transplant recipient46. Normothermic machine perfusion of liver for deceased donor transplant47. Organ donation after cardiac death