Main description:

Using clear and practical examples, Polymorphism of Pharmaceutical Solids, Second Edition presents a comprehensive examination of polymorphic behavior in pharmaceutical development that is ideal for pharmaceutical development scientists and graduate students in pharmaceutical science. This edition focuses on pharmaceutical aspects of polymorphism and solvatomorphism, while systematically explaining their thermodynamic and structural origins.

Topics include:

Computational methodologies
High-throughput screening methods
Pharmaceutical cocrystals
Thermally-induced and solution-mediated phase transformations
Amorphous solids
Crystallography preparation and characterization
The amorphous state

Contents:

THERMODYNAMIC AND THEORETICAL ISSUES
Theory and Principles of Polymorphic Systems, Harry G. Brittain
Application of the Phase Rule to the Characterization of Polymorphic and Solvatomorphic Systems, Harry G. Brittain
Computational Methodologies: Toward Crystal Structure and Polymorph Prediction, Sarah (Sally) L. Price

PREPARATIVE METHODS FOR POLYMORPHS AND SOLVATOMORPHS
Classical Methods of Preparation of Polymorphs and Alternative Solid Forms, Peter W. Cains
Approaches to High-Throughput Physical Form Screening and Discovery, Alastair J. Florence

STRUCTURAL PROPERTIES OF POLYMORPHS AND SOLVATOMORPHS
Structural Aspects of Polymorphism, Harry G. Brittain, Stephen R. Byrn, and Eunhee Lee
Structural Aspects of Solvatomorphic Systems, Harry G. Brittain, Kenneth R. Morris, and Stephan X. M. Boerrigter
Pharmaceutical Co-crystals: A New Opportunity in Pharmaceutical Science for a Long-Known but Little-Studied Class of Compounds, Kapildev K. Arora and Michael J. Zaworotko

CHARACTERIZATION METHODS FOR POLYMORPHS AND SOLVATOMORPHS
Thermoanalytical and Crystallographic Methods, Sisir Bhattacharya, Harry G. Brittain, and Raj Suryanarayanan
Vibrational Spectroscopy, Harry G. Brittain
Solid-State Nuclear Magnetic Resonance Spectroscopy, Patrick A. Tishmack
Effects of Polymorphism and Solid-State Solvation on Solubility and Dissolution Rate, Harry G. Brittain, David J. R. Grant, and Paul B. Myrdal

INTERCONVERSION OF POLYMORPHS AND SOLVATOMORPHS
Solid-State Phase Transformations, Harry G. Brittain
Effects of Pharmaceutical Processing on the Solid Form of Drug and Excipient Materials, Peter L. D. Wildfong

SPECIAL TOPICS RELATED TO POLYMORPHISM AND SOLVATOMORPHISM
Structural Aspects of Molecular Dissymmetry, Harry G. Brittain
Amorphous Solids, Lynne S. Taylor and Sheri L. Shamblin
Index