Main description:

This volume explores current viewpoints and knowledge gaps in the field of traumatic brain injury (TBI). The chapters in this book cover topics ranging from development of in vitro and animal TBI models, to diagnostic imaging and disease monitoring in patients. Designing pre-clinical and clinical trials is also discussed. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.
Practical and thorough, Pre-Clinical and Clinical Methods in Brain Trauma Research is a valuable resource for both scientists and clinical researchers interested in learning about important techniques and their applications in the field of TBI.

Contents:

Series Preface...Preface...Table of Contents...Contributing Authors... 1. Traumatic Brain Injury Amit K. Srivastava and Charles S. Cox, Jr.
2. Three-Dimensional In Vitro Brain Tissue ModelsMin D. Tang-Schomer
3. Modeling Traumatic Brain Injury In VitroDaniel E. Bonder, Carolyn E. Keating, Namas Chandra, D. Kacy Cullen, and Bryan J. Pfister
4. Drosophila Model to Study Chronic Traumatic EncephalopathyRojahne Azwoir and Liam Chen
5. Controlled Cortical Impact for Modeling Traumatic Brain Injury in AnimalsNicole Osier and C. Edward Dixon
6. Fluid Percussion Model of Traumatic Brain InjuryRachel K. Rowe, Daniel Griffiths, and Jonathan Lifshitz
7. Development of a Rodent Model of Closed Head Injury: The Maryland Model Erik Hayman, Kaspar Kaledjian, Vladimir Gerzanich, and J. Marc Simard
8. Rodent Model of Primary Blast-Induced Traumatic Brain Injury: Guidelines to Blast MethodologyVenkatasivasai Sujith Sajja, Arun Peethambaram, Stephen A. Van Albert, and Joseph B. Long
9. Cognitive and Motor Function Assessments in Rodent Models of Traumatic Brain InjuryDanielle Scott and Kathryn E. Saatman
10. Pre-Procedural Considerations and Post-Procedural Care for Animal Models with Experimental Traumatic Brain InjuryMary A. Robinson, Samer M. Jaber, Stacey L. Piotrowski, and Thomas H. Gomez
11. Laser Capture Microdissection of Single Cells, Cell Populations, and Brain Regions Affected by Traumatic Brain InjuryHarris A. Weisz, Deborah R. Boone, Stacy L. Sell, and Helen L. Hellmich
12. Rat Microglia Isolation and Characterization Using Multi-Parametric Panel for Flow Cytometric AnalysisNaama E. Toledano Furman, Karthik S. Prabhakara, Supinder Bedi, Charles S. Cox Jr., and Scott D. Olson
13. The Principles of Experimental Design and the Determination of Sample Size When Using Animal Models of Traumatic Brain Injury Michael F.W. Festing
14. Advanced Informatics Methods in Acute Brain Injury ResearchJude P.J. Savarraj, Mary F. McGuire, Ryan Kitagawa, and Huimahn Alex Choi
15. Rapid Detection and Monitoring of Brain Injury Using Sensory Evoked ResponsesJonathan A. N. Fisher and Cristin G. Welle
16. Advanced Neuroimaging Methods in Traumatic Brain InjuryJenifer Juranek
17. Dynamic Contrast Enhanced MRI for the Analysis of Blood-Brain Barrier Leakage in Traumatic Brain Injury Qiang Shen and Timothy Q. Duong
18. Assessments for Quantifying Neuromotor Functioning after Repetitive Blast ExposureChristopher K. Rhea, Nikita A. Kuznetsov, W. Geoff Wright, F. Jay Haran, Scott E. Ross, and Josh L. Duckworth
19. Translingual Neurostimulation (TLNS): Perspective on a Novel Approach to Neurorehabilitation after Brain InjuryYuri Danilov and Dafna Paltin
20. The Rapid Templating Process for Large Cranial DefectsJeremy Kwarcinski, Philip Boughton, Andrew Ruys, and James van Gelder
21. Computer-Assisted Approaches to Identify Functional Gene Networks Involved in Traumatic Brain InjuryAnthony San Lucas, John Redell, Pramod Dash, and Yin Liu
22. Clinical Trials for Traumatic Brain Injury: Designs and ChallengesJuan Lu and Mirinda Gormley