Main description:

Drugs arising from new insights gained into the molecular genetics of disease development and progression account for a significant proportion of pharmaceutical sales. Several enabling technologies have been developed over recent years which have made this new drug discovery revolution possible. The confluence of these novel technologies with the coordination of international effort, and the rapid dissemination of new knowledge has led to particularly rapid progress. This progress has been so startling that many now speak of personalising pharmacotherapy on the basis of genetic profiling of the patient.

The aim of Principles and Applications of Pharmacogenomics is to provide an understanding of the genetic sciences underpinning the development of modern drugs and to explain the genetic and environmental bases of variability in human response to those drugs. It does so through an unravelling of the core scientific principles and careful choice of illustrative examples drawn from the current literature. Principally written for all those with an interest in pharmacogenetics, including pharmacologists, pharmacists, drug developers in the pharmaceutical industry and drug regulators, the evidence–based perspective adopted should also provide a valuable text for undergraduates in pharmacy and clinical pharmacology.

Back cover:

Drugs arising from new insights gained into the molecular genetics of disease development and progression account for a significant proportion of pharmaceutical sales. Several enabling technologies have been developed over recent years which have made this new drug discovery revolution possible. The confluence of these novel technologies with the coordination of international effort, and the rapid dissemination of new knowledge has led to particularly rapid progress. This progress has been so startling that many now speak of personalising pharmacotherapy on the basis of genetic profiling of the patient.

The aim of Principles and Applications of Pharmacogenomics is to provide an understanding of the genetic sciences underpinning the development of modern drugs and to explain the genetic and environmental bases of variability in human response to those drugs. It does so through an unravelling of the core scientific principles and careful choice of illustrative examples drawn from the current literature. Principally written for all those with an interest in pharmacogenetics, including pharmacologists, pharmacists, drug developers in the pharmaceutical industry and drug regulators, the evidence–based perspective adopted should also provide a valuable text for undergraduates in pharmacy and clinical pharmacology.

Contents:

Section 1.

Chapter 1 Historical Perspectives and the promise of personalized therapy.

Chapter 2 Causes of variability in human drug response.

Chapter 3 Genes and the Human Genome.

Chapter 4 Developing better drugs through genomics.

Chapter 5 Genetically–engineered drugs.

Chapter 6 Monoclonal antibodies.

Chapter 7 Gene therapy.

Chapter 8 Gene silencing.

Chapter 9 Cell–based therapy.

Chapter 10 Genetic Testing to personalise treatment.

Chapter 11 Ethnicity and pharmacogenomics.

Chapter 12 Paying for the fruits of pharmacogenomics research.

Chapter 13 Drug Regulatory Perspectives.

Chapter 14 Ethical dilemmas.

Section 2.

Chapter 15 Case study 1: Pharmacogenetics of cancer.

Chapter 16 Case study 2: Pharmacogenetics of Schizophrenia.

Chapter 17 Case study 3: Pharmacogenetics of anticoagulant therapy.

Chapter 18 Case study 4: Pharmacogenetics in anaesthesia.

Chapter 19 Case study 5: Pharmacogenetics of adverse drug reactions.

Section 3.

Chapter 20 How drugs work: introduction to drug action.

Chapter 21 Polymorphisms of metabolic enzymes.

Chapter 22 Polymorphisms of drug receptors and transporters.

Chapter 23 Cost–effectiveness assessment in pharmacogenetics.

Chapter 24 Laboratory techniques in pharmacogenetics.

Chapter 25 Meta–analysis in pharmacogenetics.

Chapter 26 Pharmacoepigenetics.

Chapter 27 Basic statistical methods in pharmacogenomics