Main description:

This first comprehensive treatment of the subject for more than a decade includes the latest research on nanoparticle toxicology. The practical handbook addresses all areas where toxic mixtures are encountered, from environmental via occupational to medical settings, giving special consideration to air and water, and to the specific requirements for study design in mixture toxicology. While no extensive prior knowledge or toxicological experience is required, the practice-oriented case studies and examples in the second part make this the ideal companion for the professional toxicologist in industry or healthcare institutions with little time for academic study.

Contents:

Chemical Mixtures in the Environment: Exposure Assessment Application of a Relative Potency Factor Approach in the Assessment of Health Risks Associated with Exposures to Mixtures of Dioxin-Like Compounds Statistical Methods in Risk Assessment of Chemical Mixtures Kinetic Interactions of Chemical Mixtures Toxicological Interaction Thresholds of Chemical Mixtures Characterization of Toxicoproteomics Maps for Chemical Mixtures Using Information Theoretic Approach Pharmacokinetic Mechanisms of Interactions in Chemical Mixtures Chemical Mixtures and Cumulative Risk Assessment Application of ATSDRs Mixtures Guidance for the Toxicity Assessment of Hazardous Waste Sites Application of Mixture Methodology for Workplace Exposures Assessing Risk of Drug Combinations Dermal Chemical Mixtures Synergy: A Risk Management Perspective Chemistry, Toxicity, and Health Risk Assessment of Drinking Water Disinfection By-Products Endocrine Active Chemicals Evaluation of Interactions in Chemical Mixtures Thyroid Active Environmental Pollutants and Their Interactions on the Hypothalamic-Pituitary-Thyroid (HPT) Axis Toxic and Genotoxic Effects of Mixtures of Polycyclic Aromatic Hydrocarbons Development of In Vitro Models to Assess Toxicity of Engineered Nanomaterials The Application of Physiologically-Based Pharmacokinetics, Bayesian Population PBPK Modeling, and Biochemical Reaction Network Modeling to Chemical Mixture Toxicology Food Ingredients Are Sometimes Mixtures Biomonitoring Adverse Drug Reactions and Interactions