Main description:

The third edition of this important work is a timely update to the comprehensive textbook first published in 2002 and reissued in a second edition in 2010. The past few years have witnessed major developments in our understanding of diabetes and in therapeutic approaches to this disease and its numerous complications. Thus, all chapters have been significantly revised and updated with current evidence and best practices, and four brand new chapters are included, discussing the potential role of vitamin D in the pathogenesis of diabetes, peculiarities of diabetes in the elderly, oral manifestations of diabetes, and the current state of bariatric surgery.

Written by an international group of experts and carefully edited by a leading authority on the subject, Principles of Diabetes Mellitus, Third Edition is an invaluable resource for researchers and physicians of all specialties, as well as medical students and investigators of all aspects of diabetes, who deal with an illness that has reached epidemic proportions.

Contents:

Part I.- The Main Events in the History of Diabetes Mellitus.- Part II: Physiology of Glucose Metabolism.- Normal Glucose Homeostasis.- Endocrine Pancreas.- The Role of Incretins in Insulin Secretion.- Cellular Mechanisms of Insulin Action.- The Role of Brain in Glucose Metabolism.- Part III: Diagnosis and Epidemiology of Diabetes.- Diagnostic Criteria and Classification of Diabetes.- Epidemiology.- Diabetes in Culturally Diverse Populations: From Biology to Culture.- Part IV: Genes and Diabetes.- Genetics of Type 2 Diabetes: From Candidate Genes to Genome-Wide Association Analysis.- Rodent Models of Diabetes.- Part V: Diabetes Syndromes.- Type 1 Diabetes Mellitus: Epidemiology, Genetics, Pathogenesis, and Clinical Manifestations.- Type 2 Diabetes Mellitus: Epidemiology, Genetics, Pathogenesis, and Clinical Manifestations.- Maturity-Onset Diabetes of the Young: Molecular Genetics, Clinical Manifestations, and Therapy.- Diabetes in Pregnancy.- Secondary Causes of Diabetes Mellitus.- Syndromes of Extreme Insulin Resistance.- Oral Manifestations of Diabetes.- Part VI: Complications of Diabetes.- Acute Hyperglycemic Syndromes: Diabetic Ketoacidosis and the Hyperosmolar State.- Hypoglycemia in Diabetes Mellitus.- Intake of Advanced Glycation Endproducts: Role in the Development of Diabetic Complications.- Diabetic Retinopathy.- Diabetic Nephropathy.- Diabetic Neuropathy.- Peripheral Vascular Disease in Diabetes.- The Diabetic Foot.- Male Sexual Dysfunction in Diabetes Mellitus.- Gastrointestinal Manifestations of Diabetes.- Dyslipidemia: Pathogenesis and Management.- Dermatological Complications of Diabetes Mellitus: Allergy to Insulin and Oral Agents.- Part VII: Related Disorders.- Obesity - Genetics, Pathogenesis, Therapy.- Hypertension.- Coronary Artery Disease and Cardiomyopathy.- Polycystic Ovary Syndrome.- Insulin Resistance and the Metabolic Syndrome.- Diabetes and Liver Disease.- The Increased Risk of Cancer in Obesity and Type 2 Diabetes: Potential Mechanisms.- Diabetes and Sleep Disorders.- HIV Infection and Diabetes.- Part VIII: Therapy of Diabetes Mellitus - General Principles.- Glycemic Goals.- Behavioral and Educational Approaches to Diabetes Self- Management.- Dietary Therapy of Diabetes Mellitus.- Exercise in the Therapy of Diabetes Mellitus.- Therapy of Type 1 Diabetes Mellitus.- Treating Type 2 Diabetes Mellitus.- Prevention of Microvascular Complications of Diabetes - General Overview.- Psychiatric Care of the Patient with Diabetes.- Management of Diabetes and Hyperglycemia in the Hospital Setting.- The Future of Diabetes Therapy.- Part IX: Diabetes Prevention.- Prevention of Type 1 Diabetes Mellitus.- Prevention of Type 2 Diabetes Mellitus.- Part X.- Resources for Patients with Diabetes.