Main description:

Hypoxia is and remains a major public health issue in many populated mountainous areas all over the world. This book is directly derived from a NATO-sponsored international meeting on problems of high altitude medicine and biology, which was held on the shores of lake Issyk-Kul, in Kyrghyzstan, in 2006. Overall, the meeting was an ideal mix of cell biology, integrative physiology and medical applications.

Contents:

1. 45 Years of mountain medicine; J.S. Milledge.- 2. High altitude pulmonary hypertension and chronic mountain sickness; D. Penaloza.- 3. The Cellular effects of hypoxia on the pulmonary circulation; A. Peacock et al.- 4. Angiogenesis and chronic hypoxic pulmonary hypertension; S. Eddahibi et al.- 5. Tetrahydrobiopterin and pulmonary hypertension; L. Zhao et al.- 6. Hypoxia-induced proliferation of human pulmonary arterial smooth muscle cell is involved in the suppression of cyclin-dependent kinase inhibitors; T. Ishizaki et al.- 7. Pulmonary adaptation to high altitude in wild mammals; S. Akio et al.- 8. Lung at high altitude: between physiology and pathology; A. Cogo et al.- 9. Sildenafil and hypoxic pulmonary hypertension; B. Kojonazarov et al.- 10. The role of antioxidants in modulation of acclimatization processes; A.Z. Zurdinov.- 11. Gene polymorphisms and high altitude pulmonary hypertension; A.A. Aldashev.- 12. Genetic factors in the acute response to hypoxia in animals models; K.P. Strohl.- 13. Who gets high altitude pulmonary edema and why?; P. Bartsch et al.- 14. Effects of inhaled nitric oxide and oxygen in high altitude pulmonary edema; I.S. Anand.- 15. Altered autoregulation of cerebral blood flow in hypoxia. Relevance to the pathophysiology of acute mountain sickness; R. Naeije, A. van Osta.- 16. Cardiac limitation to exercise capacity at high altitudes; S. Huez et al.- 17. Pediatric high altitude heart disease: a hypoxic pulmonary hypertension syndrome; Tian-Yi Wu.- 18. Clinical and functional features of COPD at the highlanders of Kyrgyzstan; T.M. Sooronbaev et al.- 19. Monitoring of morphological and functional parameters of platelets at patients with thrombocytopenic purpura during high mountains treatment; A.R. Raimjanov et al.- 20. Role of exogenous hypoxia in treatment of chronic Glomerulonephritis; R.R. Kaliev, M.M. Mirrakhimov.- 21. Atherogenesis of brain vessels in conditions of hypoxia at Kyrgyz highlanders; T.K. Kadyraliev.- 22.Particularities of Neuropsychotropic Effects of Mexidol in Conditions of Various Altitude; U.M. Tilekeeva et al.- 23. Influence of high-altitude hypoxia on adaptive and dysadaptive structural changes in the vessels of the pulmonary circulation vessels; T.K. Kadyraliev et al.- 24. Acute Oxygen Sensing Mechanisms; E.K. Weir.