Main description:

This is the first book to collect and summarize in one publication the efforts to use kinases or phosphatases for drug development against parasite infections. The editors and contributors comprise the Who?s Who in the field, and they are comprehensive in covering every aspect of the topic, from basic research findings to translational approaches in drug development The result will be welcomed by everyone in academia and industry participating in the global effort to finally combat the major diseases caused by eukaryotic parasites. This is volume one of a two-volume treatise, the second being exclusively dedicated to efforts to combat malaria using the same approach.

Contents:

Foreword: Prof. Phil Cohen? Section 1: Bioinformatics David Roos and Diego Miranda-Saavedra: Apicomplexan kinomes Marylin Parsons and Jeremy Mottram: Trypanosomatid kinomes Mikhail Kutuzov and Alexandra Andreeva: Parasite phosphatomes Dan Zilberstein and Gerald Spaeth: The contribution of phosphoproteomics to Leishmania biology Michael Urbaniak and Michael Ferguson: Trypanosome phosphoproteomics Section 2: Functional analysis of parasite kinomes and phosphatomes Tansy Hammarton: Trypanosome cell division kinases Michael Boshart: Trypanosome AGC kinases Keith Matthews: Trypanosome phosphatases Gerald Spaeth and Martin Wiese: Leishmania MAP kinases David Roos and Jean-Francois Dubremetz: Toxoplasma ROP kinases Wes Van Voorhis: Calcium-dependent kinases in Apicomplexa Dan Goldberg: Plasmodium stress-responsive kinases Sanghamitra Raha : Entamoeba kinases Guilherme Oliveira: The Schistosoma kinome Section 3: Role of host cell kinomes and phosphatomes in parasitic infections Maria Mota: Host hepatocyte signaling during Plasmodium infection Bhaskar Saha : Macrophage kinases in Leishmania infection Barbara Burleigh: Host kinases in T. cruzi infection Anthony Sinai: Host kinases in Toxoplasma gondii infection Kerry Woods and Dirk Dobbelaere: Hijacking of host cell signaling by Theileria Section 4: Drug discovery Didier Leroy: overview Raymon Hui: Structural basis for parasite-directed selectivity of kinase inhibitors Jose Garcia / Javier Gamo or Kip Guy or Elizabeth Winzeler: Cellular screens on malaria parasites Paul M. Selzer: CDKs in Eimeria as Drug Targets Laurent Meijer and Wes Van Voorhis: GSK3 of parasitic protists as targets Christophe Bodenreider and Thierry Diagana: Plasmodium CK2 as target Nick Wilkinshaw: Bioinformatics approaches in the search of parasite kinase inhibitors Dal Peraro and Roman Affentrager/Jeff Wiseman: In silico docking in the search of parasite kinase inhibitors Andrew Wilks: Affinity-based drug discovery applied to Plasmodium kinases Colette Dissous and Christoph Grevelding : Schistosoma receptor tyrosine kinases as targets