Main description:

This volume looks at classic and novel methods currently used by researchers to understand mood and anxiety disorders and foster precision medicine. Chapters in this book cover topics such as how the sucrose preference succeeds or fails as a measurement of anhedonia; fear conditioning in laboratory rodents; animal models for mania; rodent models for studying the impact of variation in early life mother-infant interactions on mood and anxiety; and prediction of susceptibility/resilience toward animal models of PTSD. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.

Comprehensive and cutting-edge, accommodating the novel views on how the neurobiology of psychiatric disorders should be reconceptualized, Psychiatric Vulnerability, Mood, and Anxiety Disorders: Tests and Models in Mice and Rats is a valuable resource for all researchers interested in learning more about this important and developing field.

Contents:

1 Animal Models of Mood and Anxiety Disorders: The Pursuit of Standardization and Recognition of the Complex Neurobiology of Human Mental Health

Jaanus Harro

2 The Open Field Test

Vootele Voikar and S. Clare Stanford

3 The Light Dark Box Test in the Mouse

Solal Bloch and Catherine Belzung

4 The Olfactory Bulbectomized Rodent Remains a Valuable Preclinical Model of Depression and Antidepressant Activity

Michelle Roche and John P. Kelly

5 Marble-Burying in Mice

Jeffrey M. Witkin and Jodi L. Smith

6 How the Sucrose Preference Succeeds or Fails as a Measurement of Anhedonia

Tatyana Strekalova

7 A Vogel Conflict Test Using Food Reinforcement in Mice

Jeffrey M. Witkin and Jodi L. Smith

8 Fear Conditioning in Laboratory Rodents

Iris Muller and Markus Fendt

9 Learned Helplessness in Rodents

Kennia Moura Silveira and Samia Joca

10 Chronobiology of Mood States: Introducing Circadian Animal Models

Jorge Mendoza, Noemi Billon, Guillaume Vanotti, and Viviane Pallage

11 Telemetry in Rats and Mice: Methodological Considerations and Example Studies of Stress and Anxiety in Ground-Based Spaceflight Analogs

Laurie L. Wellman, Austin M. Adkins, Hargsoon Yoon, Richard A. Britten, and Larry D. Sanford

12 Utility and Implementation of Oral Corticosteroid Exposure in Behavioral Neuroscience Research with Rodents

Michelle K. Sequeira, Jane R. Taylor, and Shannon L. Gourley

13 Animal Models for Mania

Kirsten Schmerder and Nadja Freund

14 Social Behavior Testing in Mice: Social Interest, Recognition, and Aggression

Amy E. Clipperton-Allen and Damon T. Page

15 Rodent Models for Studying the Impact of Variation in Early Life Mother-Infant Interactions on Mood and Anxiety

Hannah E. Lapp and Frances A. Champagne

16 Principles of Recording Rodent Ultrasonic Vocalizations

Stefan M. Brudzynski and Sylvie Granon

17 Development of a Selectively Bred Mouse Model of Dominance and Submissiveness: Technical Considerations

Albert Pinhasov, Elena Shmerkin, Lev Libergod, Michael Kirby, Oryan Agranyoni, Liudmila Vinnikova, and Debpali Sur

18 Prediction of Susceptibility/Resilience Toward Animal Models of Post-Traumatic Stress Disorder (PTSD)

Maria Morena, Giulia Federica Mancini, and Patrizia Campolongo