Main description:

This book gives an overview of therapeutic drug monitoring (TDM) and its clinical application. It also highlights recent advances in toxicological studies, as they relate to therapeutic drug monitoring.

This is one of the few books available on the market that covers TDM. Therapeutic drug monitoring (TDM) is a clinical decision-making tool that enables dosage regimen adjustments based on clinical and laboratory measurements. TDM not only involves the measuring of drug concentrations but also interpretation of the results. There is a strong correlation between drug concentrations in body fluids and outcome than between dose and outcome. The chapters include coverage of analytical techniques, pharmacokinetics, therapeutic indices, artificial intelligence and recent advances in toxicological studies.

The book fills a gap in published literature and provides reliable information on;

Analytical techniques in TDM and clinical toxicology
TDM and pharmacokinetic studies
TDM of drugs with narrow therapeutic indices
Artificial intelligence in TDM and clinical toxicology
Future directions and challenges

Contents:

Chapter Titles
1 Therapeutic and toxic concentration of drugs in biological matrices
2 Analytical techniques for therapeutic drug monitoring and clinical toxicology
3 Plasma therapeutic drug monitoring and clinical toxicology
4 Dried blood spots in therapeutic drug monitoring and toxicology
5 The role of artificial intelligence in therapeutic drug monitoring and clinical toxicity
6 Therapeutic drug monitoring and optimal pharmacotherapy with medicines of narrow therapeutic index
7 Therapeutic drug monitoring (TDM) and toxicological studies in alternative biological matrices
8 Analyzing data from therapeutic drug monitoring, pharmacokinetics, and clinical toxicology studies
9 Reducing toxicity in critically ill patients by using therapeutic drug monitoring
10 Quality assurance of samples for therapeutic drug monitoring and clinical toxicology
11 Therapeutic drug monitoring and toxicology of anticancer drugs
12 Therapeutic drug monitoring and toxicology of immunosuppressant
13 Therapeutic drug monitoring and toxicology: relevance of measuring metabolites
14 Recent advances in nanosensors for Therapeutic Drug Monitoring (TDM)
15 Organ toxicity by immunosuppressive drugs in solid organ transplantation
16 Artificial intelligence-based techniques to assess drug toxicity in drug induced liver injury (DILI) disease
17 Drug dose and therapy individualization
18 Models for drug individualization: patient to population level
19 Toxicity evaluation of nanomedicine
20 Biochemical indices of drug toxicity
21 Therapeutic drug monitoring and clinical toxicology: challenges and future directions