Main description:

Overexpression of receptor tyrosine kinases (RTKs) has been implicated in cancer. Increasing evidence suggests that dysregulation of RTKs is reported in many neurodegenerative and psychiatric disorders.

Receptor tyrosine kinases in Neurodegenerative and Psychiatric disorders book provides a fundamental, pragmatic map of RTKs structure, activation, functions, mechanism of action, gene regulation, and signaling pathways in developing CNS, adult normal CNS, neurodegenerative and psychiatric disorders. Additionally, the structure, function, activation, and therapeutic potential of many growth factors have been covered. Here, international experts in the field offer a comprehensive discussion of results of pre-clinical and clinical studies of repositioning of anti-cancer receptor RTKIs and other promising protein kinase inhibitors in various neurodegenerative disorders including, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis, and psychiatric disorders including, anxiety, depression, alcohol use disorder, and schizophrenia. In addition, the book discusses the obstacles and opportunities for the potential repositioning of kinase inhibitors in neurodegenerative and psychiatric disorders.

Contents:

Chapter 1: The Molecular Pathology of Neurodegenerative And Psychiatric Disorders

Alzheimer's Disease
Parkinson's Disease
Multiple Sclerosis
Psychiatric Disorders

Chapter 2: Receptor Tyrosine Kinases (RTKs): An Overview

Receptor tyrosine kinases (RTKs) Families and Subfamilies
Receptor tyrosine kinase (RTKs) signaling
Biological expression and functions in the brain and other tissues
Roles of RTKs in several diseases
Molecular mechanisms of receptor tyrosine kinase-mediated neurodegeneration
Current status of receptor tyrosine kinases inhibitors as therapeutic targets

Chapter 3: Roles of TRK Receptors, Tyrosine Kinase Receptors for Neurotrophins in the Developing CNS

Intracellular signaling via Trk tyrosine kinase receptors
Role of brain-derived neurotrophic factors/tropomyosin receptor kinase B (BDNF/TrkB) system in synaptic function
Synaptic proteins and neurotrophins/receptors system
Role of tropomyosin receptor kinase (TrkR) and P75 neurotrophin receptors (p75NTR) in neurogenesis
Aging and neurotrophins receptors
Neurotrophins/Receptors signaling in Alzheimer's disease

Chapter 4: Role Of Receptor Tyrosine Kinase In The Central Nervous System In Health And Disease

1. Structure of receptor tyrosine kinases (RTKs)

2. Activation of RTKs in a healthy central nervous system (CNS)

3. Classification of RTKs

4. Role of RTKs in healthy CNS

5. Expression and activation of RTK in neurodegenerative disorders

6. Expression and activation of RTK in Psychiatric disorders

7. Concluding remarks

Chapter 5: Growth Factors and Their Receptors: Multitasking Functionality in Health and Disease

Neurodegenerative Diseases
Management of Psychiatric Disorders in Relations with Neurodegenerative diseases
Role of Receptor Tyrosine Kinase (RTK) in cell signaling
Activation of Receptor tyrosine kinase (RTK)
Major Classes of Growth Factors Acting in the Nervous System
Growth Factor as Therapeutic Strategies in NDDs: Future Prospects

Chapter 6: Regulation of Receptor Tyrosine Kinase Gene Expression

Receptor tyrosine kinase genes
Regulation of receptor tyrosine kinase gene expression
Mechanism of receptor tyrosine kinase activation
Regulation of receptor tyrosine kinase activity
Downstream effectors of RTKs regulating the pathophysiology of neurodegenerative diseases and Psychiatric disorders

Chapter 7: Role Of Receptor Tyrosine Kinases (RTKs) In Neurodegenerative Disorders

Role of receptor tyrosine kinases (RTKs) in Alzheimer's disease
Role of receptor tyrosine kinase (RTKs) in Parkinson's disease (PD)
Role of RTKs in Amyotrophic lateral sclerosis (ALS)
Role of RTKs in Multiple sclerosis

Chapter 8: Receptor Tyrosine Kinase Signaling in Neurodegenerative Disorders

Rearranged during transfection (RET) receptors
Epidermal Growth Factor Receptor (EGFR; HER or ErbB)
Vascular endothelial growth factor receptors (VEGFRs)
Tyro3, Axl, and Mertk (TAM receptors)
Tropomyosin receptor kinase (Trk) receptors

Chapter 9: Receptor Tyrosine Kinases in Major Depressive Disorder

Major depressive disorder
Dysregulation of Neuregulin-1/ErbB pathway in MDD
Role of tropomyosin kinase receptor B (TrkB) in MDD
Role of Fibroblast growth factor receptors (FGFRs) in MDD
Role of Ephrin (Eph) receptors in MDD

Chapter 10: Repositioning of Receptor Tyrosine Kinase Inhibitors: From Cancer to Neurodegenerative And Psychiatric Disorders

Neurodegenerative disorders (NDD)

Alzheimer's disease
Parkinson's disease
Amyotrophic lateral sclerosis
Multiple sclerosis (MS)

Psychiatric disorders

Major depressive disorder (MDD)
Schizophrenia (SCZ)

Chapter 11: Protein Kinase Inhibitors as Therapeutics in Neurodegenerative and Psychiatric Disorders: Progress, Challenges, and Recommendations

Introduction
The clinical experience
Multispecific inhibitors
Towards oligospecific inhibitors
Towards dual/monospecific inhibitors
Concluding Remarks