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Reciprocal Translation Between Pathophysiology and Practice in Health and Disease
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Main description:

Reciprocal Translation Between Pathophysiology and Practice in Health and Disease brings a novel perspective, closing the knowledge gap between normal/abnormal physiology. Chapters describe the basic mechanisms underlying a disease or trauma-related response, describe consequences in practice, and provide insights on how to use information to better understand disease outcomes. Other sections explore how these responses are beneficial and driven by similar hormones and inflammatory immune cell derived modulators. This is a must-have resource for those seeking an authoritative and comprehensive understanding on how to treat the basic mechanisms underlying disease or trauma-related responses.
With contributions from Petronella L.M. Reijven.


Contents:

PART I. PATHOPHYSIOLOGICAL MECHANISMS IN DISEASE
1. Reciprocal translation between pathophysiology and practice in health and disease
2. General principles of the repair mechanism
3. Cardiovascular responses to injury
4. Insulin resistance as an adaptive mechanism
5. Hypercholesterolemia, harm or benefit?
6. Macronutrient metabolism in starvation and stress
7. The role of ectopic adipose tissue: benefit or deleterious overflow?
8. The gut/liver axis, inflammation and the pathogenesis of metabolic syndrome
9. Harm and benefit of the inflammatory response
PART II. CLINICAL MANIFESTATIONS OF ADAPTIVE PATHOPHYSIOLOGY
10. The beneficial role of inflammation and metabolic cycling (Warburg revisited)
11. From hepatic encephalopathy to the quality of food protein and pro-tein requirements: a serendipitous journey
12. The underlying metabolism of hypoalbuminemia and its clinical effects
13. Cardiovascular stress syndromes
14. The benefit of moderate hyperglycemia and hyperlactatemia in critical illness or synthesis of biomass
15. Anemia as an adaptive phenomenon
16. Vitamin D in health and disease
PART III. IMPLICATIONS FOR TREATMENT
17. Decreases of plasma solutes in health and disease: deficiency or resulting from changing binding proteins and distribution volume?
18. Comparable metabolism in pregnancy and cancer: a universal role of the Warburg effect
19. Nutritional assessment and the role of pre-existent inflammation with a bearing on COVID-19
20. The harm afflicted by NSAIDs, statins and oral antidiabetics by blocking adaptive inflammatory metabolism
21. Benefit and concern of ketogenic and vegan diets: a revisit to pathophysiology
PART IV. MECHANISMS PROVIDING INSIGHT IN A FEW ENIGMATIC SYNDROMES
22. Pathophysiology in practice: How to manage gastrointestinal surgery in acute and elective disease conditions
23. The pathophysiology underlying the obesity and plasma cholesterol paradoxes
24. The final conclusion: dogma, bias and big data


PRODUCT DETAILS

ISBN-13: 9780128202050
Publisher: Elsevier (Academic Press Inc)
Publication date: April, 2021
Pages: 275
Weight: 700g
Availability: Available
Subcategories: Physiology

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