Main description:

Regenerative Hepatology and Liver Transplantation, Volume Two in the Regenerative and Transplant Medicine series, is an essential resource as no field in the biomedical sciences has seen more interest than organ transplantation with regard to regenerative medicine, primarily because of the urgent need to improve transplant outcomes and increase transplantation rates. The goal of this book is to bridge regenerative and transplant medicine by illustrating the state-of-the-art of clinical liver transplantation, as well as of the progress of regenerative medicine (RM) investigations aimed at the bioengineering, regeneration and repair of the liver.

This volume will be well-recognized in the current global trend toward increasing organ donation by utilizing such cutting-edge technologies. Written by the world's experts in the field of liver disease, it is perfect for transplant operators, researchers, regenerative medicine operators, tissue engineering operators, biotech operators, and those in academia, industry and regulatory agencies working to advance the field.

Contents:

Part 1 The Liver and Liver Diseases 1. The Liver: structure, physiology and metabolism 2. Prevalence of liver disease around the world 3. Viral Hepatitis 4. Non-alcoholic steatohepatitis 5. Alcoholic liver disease 6. Inborn errors of metabolism 7. Liver fibrosis/cirrhosis 8. Biomarkers in liver diseases / Precision Medicine

Part 2 Liver Transplantation 9.Living donor Liver Transplantation 10.Pediatric Liver transplantation 11.Small-for-size syndrome in Liver transplantation 12.New Indications for Liver Transplant 13.Clinical trials design and endpoints in liver transplantation 14.Oncologic liver Transplantation 15. Hepatocellular carcinoma Management 16.Marginal Donors to Expand the donor Pool 17.Domino Transplantation 18.Xenotransplantation

Part 3 Cell Transplantation 19. Hepatocyte Transplantation 20. Alginate encapsulated hepatocyte transplantation 21. Mesenchymal Stem Cell Transplantation 22. Fetal Hepatoblast Transplantation 23. Biliary Tree Stem Cell Transplantation 24. Liver Organoids

Part 4 Liver Preservation and Machine perfusion 25. General Principles of Organ Preservation in Liver transplantation 26. Machine perfusion preservation Types and Principles 27. Ischemia-Reperfusion injury 28. Clinical trials with liver machine preservation

Part 5 Regenerative Medicine in Liver Disease and Transplantation 29. Liver Regeneration 30. Gene Therapy in Liver Transplantation 31. Liver Bioengineering 32. Bioprinting of livers 33. Nanotechnology application in Liver Transplantation 34. Acute Liver Failure and Bioreactors/Liver Assist devices 35. Liver Organoids 36. Liver Bud 37. hPSC-derived liver cells for transplantation 38. Genome edited humanized pigs for human liver generation 39. Liver aging