Main description:

Senescence, Mitochondria and Senotherapeutics, Volume 136 offers updates on this unique topics, with chapters covering Cellular Senescence in Aging: Molecular Basis, Implications and Therapeutic Interventions, Mitochondria-associated Cellular Senescence Mechanisms: Biochemical and Pharmacological Perspectives, Mitochondria in cell senescence: Friend or Foe?, The role of mitochondria and mitophagy in cell senescence, Small molecules targeting mitochondrial dysfunction for potential senotheraputics, Senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction, Mitochondrial targeting peptides and probes, Mitochondria-derived peptides in healthy ageing and therapy of age-related diseases, and much more.

Other sections cover Targeting of mitostasis-proteostasis axis by antioxidant polysaccharides in neurodegeneration, Phytotherapeutic targeting of the mitochondria in neurodegenerative disorders, Melatonin as mitochondria-targeted drugs, Coenzyme Q-related compounds to maintain healthy mitochondria during aging, Changing ROS, NAD and AMP: a path to longevity via mitochondrial therapeutics, and more.

Contents:

Cellular Senescence in Aging: Molecular Basis, Implications and Therapeutic Interventions
Madhu Dyavaiah
Mitochondria in cell senescence: Friend or Foe?
Qian Chen
The role of mitochondria and mitophagy in cell senescence
Fatma Hussain and Fozia Anjum
Mitochondria-associated Cellular Senescence Mechanisms: Biochemical and Pharmacological Perspectives
Mehmet Can Atayik and Ufuk Cakatay
Changing ROS, NAD and AMP: a path to longevity via mitochondrial therapeutics
Oleh Lushchak
Mitochondria-derived peptides in healthy ageing and therapy of age-related diseases
Siarhei Alexander Dabravolski
Senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction
Jan O. Nehlin
Melatonin as mitochondria-targeted drugs
Luciano Saso and Sibel Suzen
Coenzyme Q-related compounds to maintain healthy mitochondria during aging
Guillermo Lopez-Lluch
Targeting mitochondrial dysfunction to salvage cellular senescence for managing neurodegeneration
Abhishek Kumar Singh
Targeting the microbiota-mitochondria crosstalk in neurodegeneration with senotherapeutics
Jan Homolak
Targeting of mitostasis-proteostasis axis by antioxidant polysaccharides in neurodegeneration
Zebo Huang
Phytotherapeutic targeting of the mitochondria in neurodegenerative disorders
Kavitha Thirumurugan