Main description:

Providing definitions, clinical features and epidemiology, this handbook and reference adopts a comprehensive approach, describing in detail the various physiological systems involved. As such, it is the first to combine sepsis and non-infectious SIRS, reviewing both the biological and medical aspects of these two important syndromes. The whole is rounded off with a discussion of past, present and future therapies.

Contents:

CLINICAL ASPECTS OF SEPSIS AND SIRS Definition of Sepsis and Non-Infectious SIRS (Vincent) Epidemiology of Sepsis and Non-Infectious SIRS (Reade) Similarities of the Clinical Aspects of Sepsis and Non-Infectious SIRS (Payen) Organ Dysfunction during Severe Sepsis and Septic-like Syndromes: Epidemiology, Classification and Mechanisms (Carlet) PATHOGENS Pathogens in Sepsis : Gram-Negative Bacterial PAMPs and PRRs (Stamme) Pathogens in Sepsis : Gram-Positive Bacterial PAMPs, PRRs and Superantigens (Alexander) Pathogens in Sepsis : Fungi and Parasites (Lortholary) PHYSOPATHOLOGY OF SEPSIS AND SIRS Inflammatory Mediators (Dinarello) Apoptosis: A Potential Therapeutic Target in Sepsis and Non-Infectious Systemic Inflammation (Ayala) Role of Endothelium (Ichinose) Coagulation (Levi) Epithelial Barrier Dysfunction as a Mechanism in the Pathogenesis of Multiple Organ Dysfunction (Fink) Neural Regulation of Cytokines (Tracey) Genetic Polymorphisms and other Parameters that affect Predisposal to Infection and Outcome (Cavaillon) Altered Immune Status and Leukocytes Reprogramming (Cavaillon) EXPERIMENTAL MODELS AND THERAPIES Experimental Models of Sepsis and Non-Infectious SIRS (Chaudry) Past, Present and Future of Therapies for Sepsis and Non-Infectious Systemic Inflammation (Suffredini)