Main description:

Though the Genome Project will eventually result in the sequencing of the human genome, as well as the genomes of several other organisms, there will still be a need for good statistics for family studies of complex diseases. The papers in this volume are contributions by some of the leading researchers in the field to the current topics in statistical genetics. One section deals with DNA sequence matching and issues related to forensics, while another deals with statistical problems of modeling phylogenies and inferential difficulties related to the complex tree structures produced, as well as the method of coalescence.

Contents:

Forensics.- The DNA typing controversy and NRC II.- In dispraise of inconsistent DNA relative frequency estimates.- Quantifying the genetic structure of populations with application to paternity calculations.- Population Genetics.- Coalescent theory and its applications in population genetics.- Phylogenies: An overview.- Detecting linked genomic mutations.- Human Genetics.- Biological and statistical studies for diseases involving mtDNA mutations.- Statistical methods in human genetics.- The affected-pedigree-member method revisited under population stratification.- Triangle constraints for sib-pair identity by descent probabilities under a general multilocus model for disease susceptibility.- A statistical analysis of cancer genome variation.- List of participants.