Main description:

Substance Use and Addiction Research: Methodology, Mechanisms, and Therapeutics is an up-to-date, comprehensive, practical book on research methodologies for substance use and addiction that is intended for researchers and consumers of research information at all levels. The book is divided into four major sections, including an Introduction, Research Methodology for clinical trials, animal research and retrospective studies, Mechanisms of Use and Addiction, and Investigative Therapeutics: Designing and Measuring Outcomes. It serves a source for addressing all aspects of research design, methods and analysis within the context of the field of opioids, alcohol and other substances.

The book covers what is known in the field of quantitative and qualitative research methods, provides future directions, and introduces new models for investigation. It is organized around a translational science framework, with the contents addressing substance use/addiction research in the context of epidemiology, etiology, intervention efficacy and effectiveness, and implementation of evidence-informed interventions.

Contents:

Basics of Research Methodology
1. Reliability and validity in substance abuse and addiction research
2. Animal models
3. Translational research strategies
4. Experimental design in clinical trials Part 1
5. Experimental design in clinical trials Part 2
6. Qualitative and quantitative methods
7. Ethical issues in opioids, alcohol, other drugs and addiction-related research:
8. Informatics
9. Artificial intelligence and machine learning
10. Epidemiology and health services research methods
11. Imaging
12. Systematic review and meta-analysis

Mechanisms of abuse and addiction
13. Abuse and addiction
14. Assessment of addiction/pain and neurobiology
15. Physiological considerations in opioid addiction
16. Basic pharmacology - opioid substances
17. Basic pharmacology - non-opioid substances
18. Types of addiction
19. Substance use
20. Special study populations

Investigative Therapeutics: Designing studies and measuring outcomes
21. General therapy strategies in substance addiction
22. Alternative Therapy Strategies in Addiction
23. Drug testing and adherence monitoring
24. Pharmacogenetics - Genes, genetics, genomics and epigenetics
25. Novel therapeutic strategies effectiveness
26. Methods of psychosocial interventions
27. Principles of vaccine development
28. Drug policy analysis
29. Implementation science: Theories, models and frameworks
30. Designing and testing population-based prevention programs
31. New vistas in research