Main description:

Sulfurtransferases: Essential Enzymes for Life stands as the first comprehensive resource on this increasingly important class of enzymes. Following an introduction to the field from the Editors, each chapter covers a specific sulfurtransferase, including its basic biology and roles in healthy functioning, disease, drug discovery, and other biotechnological applications. The physiological function for each enzyme is considered in depth, along with regulation mechanisms, pharmacological inhibitors, and pathology and conditions related to altered enzymatic activity. Sulfurtransferases discussed include rhodanese, MST, thiosulfate-thiol sulfurtransferase, tRNA uracil 4-sulfurtransferase, thiosulfate-dithiol sulfurtransferases, biotin synthase, cysteine desulfurase, lipoyl synthase, molybdenum cofactor sulfurtransferase, thiazole synthase, molybdopterin synthase sulfurtransferase, molybdopterin synthase, tRNA-uridine 2-sulfurtransferase, tRNA-5-taurinomethyluridine 2-sulfurtransferase, tRNA-5-methyluridine (54) 2-sulfurtransferase, and L-aspartate semialdehyde sulfurtransferase, among others. Here, researchers will discover key knowledge and recent advances to bring forward new studies on this increasingly relevant class of enzymes, while clinicians may apply new findings in medical practice.

Contents:

1. Mercaptopyruvate Sulfurtransferase: The Molecular and Functional Properties 2. Rhodanese and Mercaptopyruvate Sulfurtransferase (EC 2.8.1.1 & EC 2.8.1.2) 3. The Tales of Fungal Sulfurtransferases: Lost, Found and Stolen 4. 3-Mercaptopyruvate Sulfurtransferase Produces Hydrogen Sulfide (H2S), Polysulfides (H2Sn) and Other S-sulfurated Signaling Molecules 5. A Persulfide Shield: An Endogenous Reactive Sulfur Species in the Forefront in the Electrophile Detoxification Pathway 6. Thiosulfate Sulfurtransferase: A Model of Essential Enzyme with Potential Applications in Medicine and Biotechnology 7. Inhibitors of Sulfurtransferase and Transsulfuration Enzymes 8. Thiosulfate-dithiol Sulfurtransferase 9. Lipoyl Synthase 10. Molybdopterin Synthase Sulfurtransferase