Main description:

This is the second edition of a very well received book that details how the sumoylation system functions and how it modulates numerous cellular activities. SUMO is a post-translational modifier in the ubiquitin super-family that has gained recognition over the last twenty years as an essential and prevalent regulatory molecule.

Individual chapters explore the biochemistry, molecular biology, and cell biology of the sumoylation system and its substrate proteins.

The book is divided into three themed parts: Molecular Functions (I), Cell Growth Regulation (II), and Diseases (III). Parts I and II focus on the contribution of sumoylation to cellular activities in both the nuclear and cytoplasmic compartments. The nuclear activities covered include nucleic acid metabolism (both RNA and DNA), chromosome structure and replication, and nucleocytoplasmic transport. Cytoplasmic processes presented include regulation of membrane ion channels, general metabolism, and apoptotic signalling. Topics in Part III include the role of sumoylation in developmental abnormalities (craniofacial and cardiovascular), diabetes, neurodegenerative diseases, cancer, and infections with viruses and bacteria.

Each of the corresponding chapter authors is an active researcher who has made significant contributions to understanding sumoylation. This second edition provides updates and revisions to most of the original chapters plus adds six new chapters to address important developing areas of sumoylation research.

This volume is intended for a scientific audience from undergraduates to independent researchers. The content will serve as both a solid introduction for the novice reader and an in depth treatment for the advanced scholar.

Contents:

Preface

1. Introduction to Sumoylation

V.G. Wilson

Part I Molecular Functions

2. Roles of Sumoylation in mRNA Processing and Metabolism

P. Richard, V. Vethantham and J.L. Manley

3. SUMO and Chromatin Remodeling

D. Wotton, L.F. Pemberton, and J. Merrill-Schools

4. Functions of SUMO in the Maintenance of Genome Stability

N. Zilio, K. Eifler-Olivi, and H.D. Ulrich

5. Regulation of Cellular Processes by SUMO: Understudied Topics

J.M. Enserink

6. The Molecular Interface Between The SUMO And Ubiquitin Systems

J.L. Staudinger

7. SUMO and Nucleocytoplasmic Transport

Christopher Ptak and Richard W. Wozniak<

8. SUMO Modification of Ion Channels

M. Benson, J.A. Iniguez-Lluhi, and J. Martens

E. Kamynina and P.J. Stover

Part II Cell Growth Regulation

10. The SUMO Pathway in Mitosis

D. Mukhopadhyay and M. Dasso

11. Wrestling with Chromosomes: The Roles of SUMO During Meiosis

A.C. Nottke, H.-M. Kim, and M.P. Colaiacovo

12. Sumoylation in Development and Differentiation

A.F. Deyrieux and V.G. Wilson

13. The Role of Sumoylation in Senescence

L.L. Scurr, S. Haferkamp, and H. Rizos

14. Regulation of Plant Cellular and Organismal Development by SUMO

N. Elrouby

15. SUMO in Drosophila Development

J. Cao and A. Courey

Part III Diseases

16. SUMOylation: Implications for Neurodegenerative Diseases

D.B. Anderson, C.A. Zanella, J.M. Henley, and H. Cimarosti

17. Sumoylation and Its Contribution to Cancer

J.S. Lee, H.J. Choi, and S.H. Baek

18. Sumoylation Modulates the Susceptibility to Type 1 Diabetes

J. Zhang, Z. Chen, Z. Zhou, P. Yang, and C.-Y. Wang

19. Sumoylation in Craniofacial Disorders

E. Pauws and P. Stanier

20. Coordination of Cellular Localization-Dependent Effects of Sumoylation in

Regulating Cardiovascular and Neurological Diseases

J. Abe, U.G. Sandhu, N.M. Hoang, M. Thangam, R.A Quintana-Quezada,

K. Fuiwara, and N.T. Le

21. Viral Interplay with the Host Sumoylation System

A.F. Deyrieux and V.G. Wilson

22. SUMOylation as an Integral Mechanism in Bacterial Infection and Disease

Pathogenesis

C.V. Srikanth and S. Verma

Index

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