Main description:

In this volume the authors promote, endorse and stimulate research in the vibrant field of biological inorganic chemistry. They provide an overview of metallodrugs which have been rationally designed to target specific biomolecules in the human body with a view to generating targeted drugs or prodrugs with widespread biomedical applications. The volume focuses on recent trends and advances in relation to targeted metallodrugs as anti-cancer, anti-microbial and anti-viral agents with an emphasis on their design, development and mode of action. It also include recent advances in the use of nanoparticles and nanoclusters as important chaperones to deliver metallodrugs to their sites of action.

Contents:

Chapter 1 Metal-Based Prodrugs Activated by Cancer-Specific Stimuli by Martijn Dijkstra, Hemma Schueffl, Isabella Poetsch, Petra Heffeter, and Christian R. Kowol. Chapter 2 Light-Activated Drugs for Photodynamic and Photoactivated Therapy by Dmytro Havrylyuk, Austin Hachey, and Edith Glazer. Chapter 3 Mitochondria as a Metallo-Drug Target for Therapeutic Purposes by Andrea Erxleben. Chapter 4 Transition Metal-Based Antiviral Agents against SARS-CoV-2 and Other Pathogenic Viruses by Maria Gil-Moles and Ingo Ott. Chapter 5 Exploiting the Chemical Diversity of Metal Compounds as a Source of Novel Anti-COVID-19 Drugs by Damiano Cirri, Tiziano Marzo, Carlo Marotta, Alessandro Pratesi, and Luigi Messori . Chapter 6 Evaluating the Potential of Novel Metal-Based Drugs for Treating Drug-Resistant Bacteria by Andris Evans and Kevin Kavanagh. Chapter 7 Prospective Metallo-Drugs Including Bioactive Compounds: Selection of Co-Ligands to Tune Biological Activity against Neglected Tropical Diseases by Dinorah Gambino and Lucia Otero. Chapter 8 Challenges in Targeting Cyanide Poisoning: Advantages in Exploiting Metal Complexes in Its Treatment by Sigridur G. Suman. Chapter 9 Advanced Microscopy Methods for Elucidating the Localization of Metal Complexes in Cancer Cells by Johannes Karges and Nils Metzler-Nolte.Chapter 10 Metalloproteomics: A Powerful Technique for Metals in Medicine by Tiffany Ka-Yan Ip, Ying Zhou, Hongyan Li, and Hongzhe Sun. Chapter 11 Metal-Based Nanoclusters for Biomedical Applications by Edit Csapo. Chapter 12 Radiometals in Molecular Imaging and Therapy by Izabela Cieszykowska, Wioletta Wojdowska, Dariusz Pawlak, and Renata Mikolajczak.