Main description:

Nonhuman primates have played critical roles in biomedical research, and they are among the few animals whose use in research continues to increase. The scienti?c value of nonhuman primates derives from their close phylogenetic proximity to man and their consequent anatomic, physiologic, and genetic similarities to man. Only nonhuman primates can provide adequate models for many complex physiological and disease processes of humans. The baboon is a relative newcomer to the repertoire of nonhuman primates used in biomedical research. However, in less than 50 years since its ?rst use in the U. S. , it has become one of the most popular laboratory primate species. It is larger than the other widely used monkey species, making it advantageous for many types of experiments and technological developments. It is extraordinarily hardy and highly fecund in captivity. It closely resembles humans in a variety of physiological and disease processes, such as cholesterol metabolism, early stages of atherosclerosis, and alcoholic liver disease. Its chromosomes closely resemble those of humans, and many genes of the two species lie in the same chromosomal order. Among all primates, baboons are the most widely used models for the genetics of susceptibility to complex diseases and they are the ?rst nonhuman primate for which a framework genetic linkage map was established. In addition, the baboon genome is currently being sequenced, and as a result the utility of this species for biomedical research will be dramatically increased.

Contents:

Preface John L. VandeBerg, Sarah Williams-Blangero, Suzette D. Tardif Introduction John L. VandeBerg The Development and Status of the Baboon Genetic Linkage Map Jeffrey A. Rogers, Michael C. Mahaney, Laura A. Cox The Study of Captive Baboon Behavior Linda Brent Spontaneous Pathology of Baboons Gene B. Hubbard Growth and Development of Baboons Steven R. Leigh Reproductive Biology of Baboons Erika K. Honore, Suzette D. Tardif Microbiology of Captive Baboons Richard Eberle, Uriel Blas-Machado, Roman F. Wolf, Gray L. White Baboon Model for Endometriosis Thomas M. D'Hooghe, Cleophas M. Kyama, Jason M. Mwenda The Baboon in Embryology and Teratology Research Andrew G. Hendrickx, Pamela E. Peterson Baboon Models for Neonatal Lung Disease Bradley A. Yoder, Donald C. McCurnin, Jacqueline J. Coalson The Baboon Model for Dental Development Leslea J. Hlusko, Michael C. Mahaney Baboon Model for Dyslipidemia and Atherosclerosis David L. Rainwater, John L. VandeBerg Baboon Model for the Study of Nutritional Influences on Pregnancy Peter W. Nathanielsz, Mark J. Nijland, Christian H. Nevill, Susan L. Jenkins, Gene B. Hubbard, Thomas J. McDonald, Natalia E. Schlabritz-Loutsevitch Baboon Model for Infant Nutrition glen E. Mott, Douglas S. Lewis Baboon Model for Ingestive Behaviors John R. Blair-West, Derek A. Denton, Robert E. Shade, Richard S. Weisinger Baboon Model for Alcoholic Liver Disease: 1973-2003
Charles S. Lieber, Maria A. Leo, Leonore M. DeCarli Baboons in Drug Abuse Research Robert D. Hienz, Elise M. Weerts Neuroimaging of Baboons Kevin J. Black, Tamara Hershey, Stephen M. Moerlein, Joel S. Perlmutter The Baboon Model of Epilepsy: Current Applications inBiomedical Research C. Akos Szabo, M. Michelle Leland, Koyle D. Knape, Jeff T. Williams The Baboon in Xenotransplant Research Leonard L. Bailey