Main description:

This book is based on the proceedings of the Enteric Nervous System conference in Adelaide, Australia, under the auspices of the International Federation for Neurogastroenterology and Motility. The book focuses on methodological strategies and unresolved issues in the field and explores where the future is heading and what technological advances have been made to address current and future questions. The Enteric Nervous System II continues in the tradition of a popular earlier volume which covered the previous meeting. Many of the same authors are contributing to this new volume, presenting state-of-the-art updates on the many developments in the field since the earlier meeting. The coverage include a wide range of topics, from structure and function of the enteric nervous system through gut motility and visceral pain. The author team includes long-established authorities who significantly contributed to the advances in ENS research over the past two decades and the new generation that will continue to contribute to advancing our understanding of the field.

Contents:

Luminal Chemoreceptors and Intrinsic Nerves- Key Modulators of Digestive Motor Function
Comparative and evolutionary aspects of the ENS
Exploring synaptic transmission in the ENS: electrophysiology, functional studies and modelling
Mucosal Serotonin
Ca2+ signaling in Interstitial cells of Cajal: The mechanistic basis for many GI motility behaviors
Identifying types of neurons in the enteric nervous system
Clinico-Pathological Features of severe gut dysmotility
Purinergic signaling in the ENS
Myogenic and neural control in concert
colonic response to physiological and chemical stimuli
Molecular targets to alleviate enteric neuropathy and gastrointestinal dysfunction
The emerging role of the gut-brain microbiota axis in neurodevelopmental disorders
A view on how enteric neurons monitor luminal content
Interaction of the microbiota and the developing ENS
Influence of the circadian rhythm on enteric nervous system function
Mechanosensitive Enteric Neurons (MEN) at work
Neurogenetic investigation of the ENS and gut motility
The shaggy dog story of enteric signaling: serotonin, a molecular megillah
Contribution of enteric neuroglial remodelling to inflammatory bowel disease and cancer evolution
Examining cellular metabolism in the enteric nervous system
Embryonic development of motility: a bottom-up approach to the workings of the intestine
Quantitative analysis of intestinal movements with spatiotemporal maps
The roles of Mas related G-protein coupled receptors in the gut
Refining Enteric Neural Circuitry by Quantitative Morphology, Transcriptomics and Function in Mice"
Extrinsic modulation of enteric circuits that regulate colon function in health and disease
Activating and Modeling ENS Circuits in Mouse Colon
Neurons, macrophages and glia: the role of intercellular communication for gut motility
Modelling development of the ENS: What's been done and what's next
Epithelial 5-HT4 receptors as a target for treating constipation and colitis
Activity in Enteric Neural circuits underlying propulsion
Contribution of the ENS to autoimmune diseases and irritable bowel syndrome