Main description:

The Lung: Development, Aging and the Environment, Third Edition provides an understanding of the multifaceted nature of lung development, aging and the environment influences of these processes. As an essential resource to respiratory, pulmonary and thoracic scientists and physicians, this book provides an interface between the "normal" and "disease" cluster of chapters, allowing for a natural complement. The interface between different lung diseases affecting the pediatric lung also adds a useful source for comparing how different lung diseases share key pathophysiological features. This same complementarity comes across in the logical line up of chapters dealing with the "normal" pediatric lung.

New research, including cell-based strategies for infant lung function, epigenetics and prenatal environmental exposure (including wildfires) on lung development and function are some of the important additions to this edition of this reference work.

Contents:

Part I: Critical Events in Normal Development and Aging 1. Lung Progenitor Cell Specification and Morphogenesis 2. Development of Airway Epithelium 3. Development of the Innervation of the Lower Airways: Structure and Function 4. The Formation of Pulmonary Alveoli 5. Pulmonary Vascular Development 6. Developmental Physiology of the Pulmonary Circulation 7. Development of Salt and Water Transport across Airway and Alveolar Epithelia 8. Physical, Endocrine, and Growth Factors in Lung Development 9. The Development of the Pulmonary Surfactant System 10. Ontogeny of the Pulmonary Immune System 11. Development of Antioxidant and Xenobiotic Metabolizing Enzyme Systems 12. Stretch and Grow: Mechanical Forces in Compensatory Lung Growth 13. Pulmonary Transition at Birth 14. Normal Aging of the Lung 15. Cell-Based Strategies for the Treatment of Injury to the Developing Lung 16. Epigenetics and the Developmental Origins of Lung Disease

Part II: Environmental Influences on Lung Development and Aging 17. Pulmonary Consequences of Preterm Birth 18. The Effects of Neonatal Hyperoxia on Lung Development 19. The Influence of Nutrition on Lung Development before and after Birth 20. Genetic Factors Involved in Susceptibility to Lung Disease 21. Effects of Environmental Tobacco Smoke during Early Life Stages 22. Nicotine Exposure during Early Development: Effects on the Lung 23. Exposure to Allergens during Development 24. The Epidemiology of Air Pollution and Childhood Lung Diseases 25. Environmental Toxicants and Lung Development in Experimental Models 26. Effect of Environment and Aging on the Pulmonary Surfactant System 27. Environmental Determinants of Lung Aging 28. Climate influences on growth, development and aging 29. Sensitivity of biomarkers for exposure 30. Sex differences in development and aging and environmental influences 31. Wildfires (influence on perinatal development and susceptible populations) 32. Infection - viral and bacterial with an emphasis on the novel coronavirus (COVID-19) 33. E-cigarette vaping 34. Microbiome in developing and aging lungs