Main description:

This book on "Renin-Angiotensin System in Cardiovascular Disease" includes 25 chapters, which are organized in three sections, namely (i) modulatory aspects, (ii) pathophysiological aspects, and (iii) pharmacotherapeutic aspects. It includes an updated as well as comprehensive knowledge about molecular and cellular aspects for the role of the renin-angiotensin system (RAS) in the pathophysiology and therapy of cardiovascular diseases such as hypertension, atherosclerosis, ischemic heart disease, and heart failure. This book emphasizes the molecular and cellular mechanisms, signaling transduction pathways involved in the development of different cardiovascular diseases due to the prolonged activation of RAS. Furthermore, biochemical mechanisms are outlined for the inhibition of this system by the blockade of angiotensin converting enzyme as well as angiotensin II type 1 receptors in patients suffering from cardiovascular abnormalities. Since cardiovascular disease is the number one cause of death worldwide, leading to approximately 17.9 million deaths each year, there is a keen interest in understanding the pathogenesis and improving its therapy. In this regard, we can attest that this book provides ample information about essential components of RAS and their role in the development of cardiovascular disease.
From the selection of recognized global experts in their area of investigation, this book can be seen to cover diverse cardiovascular aspects and molecular and cellular mechanisms of angiotensin II action for the development of different cardiovascular abnormalities. It is our contention that this book will be most suitable for promoting knowledge in the field of RAS biology and will be of great interest to health professionals involved in both experimental and clinical cardiology as well as academic investigators and cardiovascular scientists, graduate students, and fellows worldwide.

Contents:

I. INTRODUCTION
1. Naranjan S. DhallaInstitute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research CentreWinnipeg, Manitoba, CanadaEmail: nsdhalla@sbrc.caTitle: Past, present and future perspectives of renin angiotensin system
2. Anureet K. Shah Department of Kinesiology, Nutrition and Food Science, California State University Los Angeles, USAEmail: akaur23@calstatela.eduTitle: Biochemical pathways of renin angiotensin system
3. Ramesh K. GoyalDelhi Pharmaceutical Sciences and Research University New Delhi, IndiaEmail: goyalrk@gmail.comTitle: Structure-function relationships of angiotensin II receptors
4. Sukhwinder K. BhullarInstitute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research CentreWinnipeg, Manitoba, CanadaEmail: sbhullar@sbrc.caTitle: Signal transduction mechanism of angiotensin II
5. Ernesto L. SchiffrinSir Mortimer B. Davis-Jewish General HospitalMontreal, CanadaE-mail: ernesto.schiffrin@mcgill.caTitle: Renin angiotensin system: Pathophysiology and clinical implications in cardiovascular disease COVID-19 infection
II. HYPERTENSION
1. Carmine SavoiaCardiology Unit, Second Faculty of Medicine, Sant 'Andrea Hospital, Sapienza UniversityRome, Italy Email: savoiac@yahoo.itTitle: Angiotensin II and the pathogenesis of hypertension
2. Satoru Eguchi
Cardiovascular Research Center, Lewis Katz School of Medicine, Temple UniversityPhiladelphia, USAE-mail: seguchi@temple.eduTitle: Signaling transduction of angiotensin II in hypertension
3. Robert E. WiddopDepartment of Pharmacology, Monash University, ClaytonVictoria, Australia Email: robert.widdop@monash.eduTitle: Role of angiotensin II type 1 receptors in vascular remodeling in hypertension
4. Rhian M. Touyz MRC Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal Montreal, CanadaEmail: touyzr@ircm.qc.caTitle: Molecular and cellular mechanisms of renin-angiotensin system in hypertension
5. Alessandro CeliDepartment of Cardiothoracic and Vascular, University of PisaPisa, ItalyEmail: r.pedrinelli@med.unipi.itTitle: Tissue renin-angiotensin system and risks in hypertension
6. Shoji KimuraDepartment of Pharmacology, Kagawa University Medical SchoolKagawa, JapanEmail: kimura@kms.ac.jpTitle: Oxidative stress and angiotensin II-induced hypertension
7. Antony VinhDepartment of Pharmacology, Monash University, ClaytonVictoria, Australia Email: antony.vinh@monash.eduTitle: Angiotensin II: inflammatory system disorder and hypertension
8. Edward D. Sturrock Department of Integrative Biomedical SciencesUniversity of Cape TownCape Town, South AfricaE-mail: edward.sturrock@uct.ac.zaTitle: Therapeutic approaches for angiotensin receptor blockers in hypertension
III. ATHEROSCLEROSIS

1. Domenico CianfloneSan Raffaele Scientific Institute, Vita-Salute San Raffaele UniversityMilan, Italy.E-mail: cianflone.domenico@hsr.itTitle: Renin-angiotensin systems: A pivotal role in the development of atherosclerosis
2. Bernhard SchiefferDepartment of Cardiology and Angiology, Hannover Medical SchoolHannover, GermanyEmail: Schieffer.Bernhard@MH-Hannover.deTitle: Angiotensin II induced intracellular signaling pathways in pathogenesis of atherosclerosis
3. Maxime PellegrinDepartment of Heart and Vessel, Lausanne University Hospital Lausanne, SwitzerlandEmail: maxime.pellegrin@chuv.chTitle: Cellular and molecular mechanisms of Ang II: Contribution to atherosclerotic plaque vulnerability
4. Ivonne H. SchulmanNephrology-Hypertension Section, University of Miami Miller School of MedicineMiami, USAEmail: ischulman@med.miami.eduTitle: Role of angiotensin II, nitric oxide and reactive oxygen species in atherosclerosis
5. Fabrizio MontecuccoDivision of Cardiology, Foundation for Medical Researches, University Hospital of GenevaGeneva, SwitzerlandEmail: fabrizio.montecucco@medecine.unige.chTitle: The renin-angiotensin system and inflammatory processes in atherosclerotic lesion formation
6. Jawahar L. Mehta Department of Medicine, Cardiology Division, University of Arkansas for Medical SciencesLittle Rock, USAEmail: mehtajl@uams.eduTitle: Role of renin-angiotensin system in alterations in blood lipids and gene expression in atherogenesis
7. Rafaela Fernandes da SilvaDepartment of Physiology and Biophysics, Federal University of Minas GeraisBelo Horizonte, Brazil. Email: rfdasilva.ufmg@gmail.comTitle: Effects of angiotensin-converting enzyme and receptors in atherosclerosis
IV. CARDIAC ARRHYTHMIAS
1. Andreas GoetteDivision of Cardiology, University Hospital MagdeburgMagdeburg, GermanyEmail: andreas.goette@medizin.uni-magdeburg.deTitle: Effects of angiotensin II on cardiac arrhythmia and signal transduction
2. Bibiana TorokInstitute of Experimental Medicine, 1085 Budapest, HungaryEmail: torok.bibiana@koki.huTitle: Angiotensin II induced oxidative stress contribute to ventricular arrhythmias
3. Pieter Martens Doctoral School for Medicine and Life Sciences, Hasselt UniversityDiepenbeek, BelgiumEmail: pieter.martens2@zol.beTitle: Modulation of renin angiotensin system: Beneficial effect on ventricular arrhythmias
4. S. Richard Physiology and Experimental Medicine of the Heart and Montpellier FranceEmail: sylvain.richard@inserm.frTitle: ACE inhibitor and ventricular arrhythmia in ischemic heart disease
5. J. R. Sowers Diabetes and Cardiovascular Research Center, University of Missouri School of MedicineColumbia, USAEmail: Sowersj@health.missouri.edu.Title: The renin-angiotensin system modulators and cardiac arrhythmias
6. David CesarioUniversity of California Irvine Medical CenterCalifornia, USAEmail: dcesario@mednet.ucla.eduTitle: Angiotensin receptor blockers in the treatment of arrhythmias
V. HEART FAILURE
1. George W Booz The Cardiovascular Research Institute, The Texas University System Health Science CenterTemple, USA.Email: gbooz@medicine.tamu.eduTitle: Angiotensin II induced cardiac hypertrophy and heart failure
2. Paramjit S. TappiaAsper Clinical Research Institute, St. Boniface HospitalWinnipeg, CanadaE-mail: ptappia@sbrc.caTitle: Renin-angiotensin system: Role in cardiac remodeling and subcellular defects in heart failure
3. Walmor C De MelloDepartment of Pharmacology, Medical Sciences Campus, University Puerto RicoSan Juan, USA Email: wmello@rcm.upr.eduTitle: Renin-angiotensin system: Molecular and cellular mechanisms in heart failure
4. Angelica WackenforsDepartment of Internal Medicine, Lund University HospitalLund, SwedenEmail: angelica.wackenfors@med.lu.seTitle: Role of angiotensin II receptor mRNA expression in heart failure
5. Po-Len Liu Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical UniversityKaohsiung, Taiwan.Email: kisa@kmu.edu.twTitle: Renin angiotensin system: Mitochondrial dysfunction in the progression of heart failure
6. Fu-Tien ChiangDepartment of Internal Medicine, National Taiwan University College of Medicine and Hospital,Taipei, Taiwan Email: futienc@ntuh.gov.twTitle: Angiotensin II type 1 receptor: Genetic polymorphisms and heart failure
7. G.Y. Oudit
Department of Medicine, Mazankowski Alberta Heart Institute, University of Alberta Edmonton, CanadaEmail: gavin.oudit@ualberta.caTitle: Angiotensin converting enzyme 2 and angiotensin metabolism in heart failure
8. L. Zhang Department of Basic Sciences, Division of Pharmacology, Loma Linda University School of Medicine, Loma Linda, USAEmail: lzhang@llu.eduTitle: Cellular and molecular mechanisms of renin-angiotensin system blockade in heart failure: An update
9. Kazuhiro YamamotoDepartment of Internal Medicine and Therapeutics, Osaka University of Medicine Suita, JapanEmail: kazuhiro@medone.med.osaka-u.ac.jpTitle: Angiotensin II receptor antagonists: Modulation of the extracellular matrix regulatory system in heart failure