Main description:

A comprehensive reference on the state of the science for both experienced researchers and for those who are interested in discovering its many promising applications.

Examines c-di-GMP signaling from a variety of angles, beginning with an introductory chapter that compares c-di-GMP to the better-known second messenger cAMP.
Recounts the discovery of c-di-GMP, explains the important role of bioinformatics in the development and continued evolution of the field, and describes the fundamental structure, function, regulation, and integration of c-di-GMP pathways.
Explores the role of c-di-GMP in such diverse processes as flagellar biogenesis and motility, extracellular polysaccharide biosynthesis, biofilm development, virulence, and innate host immunity.

This title is published by the American Society of Microbiology Press and distributed by Taylor and Francis in rest of world territories.

Contents:

Table of Contents

I. Second Messengers: an Overview

1. Introduction to Second Messengers: Lessons from Cyclic AMP

Alan J. Wolfe

II. General Principles: the Core

2. Moshe Benziman and the Discovery of Cyclic Di-GMP

Dorit Amikam, Haim Weinhouse, and Michael Y. Galperin

3. Ubiquity of Cyclic Di-GMP Pathways: a Bioinformatic Analysis

Michael Y. Galperin

4. The Core Pathway: Diguanylate Cyclases, Cyclic Di-GMP-Specific Phosphodiesterases, and Cyclic Di-GMP-Binding Proteins

Mark Gomelsky

5. The HD-GYP Domain and Cyclic Di-GMP Signaling

Robert P. Ryan, Yvonne McCarthy, and J. Maxwell Dow

6. Methods for Cyclic Di-GMP Detection

Christopher M. Waters

7. Making, Breaking, and Sensing of Cyclic Di-GMP: Structural, Thermodynamic, and Evolutionary Principles

Dorothy Kim, John F. Hunt, and Tilman Schirmer

III. Cyclic Di-GMP and Lifestyle Choices

8. Choosing the Right Lifestyle: Regulation of Developmental Pathways by Cyclic Di-GMP

Matthew Parsek and Phillip Aldridge

9. Role of Cyclic Di-GMP in Caulobacter crescentus Development and Cell Cycle Control

Soeren Abel and Urs Jenal

10. Hierarchical Control of rdar Morphotype Development of Salmonella enterica by Cyclic Di-GMP

Ute Roemling, Kristina Jonas, OEjar Melefors, Nina Grantcharova, and Agaristi Lamprokostopoulou

11. Role of Cyclic Di-GMP in Pseudomonas aeruginosa Biofilm Development

Caroline S. Harwood

12. The Scr Circuit in Vibrio parahaemolyticus Modulates Swarming and Sticking

Linda L. McCarter

13. Roles of Diguanylate Cyclases and Phosphodiesterases in Motility and Biofilm Formation in Vibrio fischeri

Alan J. Wolfe and Karen L. Visick

14. Csr (Rsm) System and Its Overlap and Interplay with Cyclic Di-GMP Regulatory Systems

Tony Romeo and Paul Babitzke

15. Riboswitches That Sense Cyclic Di-GMP

Elaine R. Lee, Narasimhan Sudarsan, and Ronald R. Breaker

16. Role of Cyclic Di-GMP in the Regulatory Networks of Escherichia coli

Regine Hengge

17. Cyclic Di-GMP Signaling in Vibrio cholerae

Sinem Beyhan and Fitnat H. Yildiz

18. Role of Cyclic Di-GMP in Biofilm Development and Signaling in Yersinia pestis

Robert D. Perry and Alexander G. Bobrov

19. Environmental Control of Cyclic Di-GMP Signaling in Pseudomonas fluoresens: from Signal to Output

Peter D. Newell and George A. O'Toole

IV. Cyclic Di-GMP, Pathogenesis, and Host Immunity

20. Role of Cyclic Di-GMP in Vibrio cholerae Virulence

Jason T. Pratt, Rita Tamayo, and Andrew Camilli

21. Cyclic Di-GMP Signaling and Host Immunity

David K. R. Karaolis and Theodore J. Standiford

22. Bis-(3',5')-Cyclic Di-GMP: Promising Adjuvant for Vaccine Design

Thomas Ebensen, Rimma Libanova, and Carlos A. Guzman

V. Conclusions

23. Cyclic Di-GMP: Using the Past To Peer into the Future

Karen L. Visick and Alan J. Wolfe