Main description:

The identification of the role of tumor stroma-the tissue in the surroundings of cancer cells-in cancer development, progression, and metastasis has revolutionized the fields of cancer biology as well as cancer therapeutics. This book provides a comprehensive overview of this rapidly-evolving field including tumor stroma biology, therapeutic targets, molecular imaging, and advanced tumor stroma in vitro models. The book will serve as a handbook for graduate students, postgraduate researchers, pharmaceutical scientists, and biomedical engineers.

Contents:

1. The Tumor Stroma: Key Component of Solid Tumors 2. Cancer-Associated Fibroblasts: Building Blocks of the Tumor Stroma 3. Tumor-Associated Macrophages: Biological Understanding and Therapeutic Opportunities 4. Biomarkers in the Tumor Stroma and Their Clinical Relevance 5. Physical Properties of the Tumor Stroma and Therapeutic Strategies 6. TGF- Signalling in Cancer: Role and Therapeutic Targeting of the Tumour Stroma 7. Role of Integrins in the Tumor Stroma 8. MicroRNA in the Tumor Stroma: Diagnostic and Therapeutic Implications 9. Molecular Imaging of the Tumor Stroma and Beyond 10. 3D in vitro Models to Mimic the Tumor Microenvironment