Main description:

Completely updated and revised, the 28th edition of this best-selling reference provides instant access to the latest recommendations for treatment of infectious diseases in children.

For each disease, the authors provide a commentary to help select the best of all antimicrobial choices. Drug descriptions cover all antimicrobial agents available today and include complete information about dosing regimens.

TOPICS INCLUDE

Antimicrobial Therapy by Clinical Syndromes
Antimicrobial Therapy for Neonates
Choosing Among

Antibiotics
Antifungal Agents
Antiviral Agents
Antiparasitic Agents
Oral Step-down Therapy for Serious Infections
Prevention of Symptomatic Infection
Approach to Antibiotic Allergies
Antibiotic Stewardship

New in the 28th Edition

Updated recommendations on acute hematogenous osteomyelitis, based on newly published guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America, including information on a decrease in the incidence of MRSA infections, allowing the recommendation of cefazolin, again, in empiric therapy for most pediatric bone infections
Updated recommendations on influenza treatment and prophylaxis, reflecting American Academy of Pediatrics guidance for 2021-2022
Ceftazidime/avibactam now preferred over fluoroquinolones for treatment of Klebsiella pneumoniae carbapenemase-producing enteric bacilli, if susceptible
Cefiderocol, a new iron-binding siderophore cephalosporin class, recently approved in adults for treatment of many drug-resistant pathogens, particularly Acinetobacter, Stenotrophomonas, and Pseudomonas; under study in children
New dosing for posaconazole suspension formulation
New approaches to mucormycosis
Added baloxavir for children 12+ years old

Contents:

Introduction
Notable Changes to 2022 Nelson's Pediatric Antimicrobial Therapy, 28th Edition
1. Antimicrobial Therapy According to Clinical Syndromes A. Skin and Soft Tissue Infections
B. Skeletal Infections
C. Eye Infections
D. Ear and Sinus Infections
E. Oropharyngeal Infections
F. Lower Respiratory Tract Infections
G. Cardiovascular Infections
H. Gastrointestinal Infections
I. Genital and Sexually Transmitted Infections
J. Central Nervous System Infections
K. Urinary Tract Infections
L. Miscellaneous Systemic Infections
2. Antimicrobial Therapy for Neonates A. Recommended Therapy for Selected Neonatal Conditions
B. Antimicrobial Dosages for Neonates
C. Aminoglycosides
D. Vancomycin
E. Use of Antimicrobials During Pregnancy or Breastfeeding
3. Preferred Therapy for Specific Bacterial and Mycobacterial Pathogens A. Common Bacterial Pathogens and Usual Pattern of Susceptibility to Antibiotics (Gram Positive)
B. Common Bacterial Pathogens and Usual Pattern of Susceptibility to Antibiotics (Gram Negative)
C. Common Bacterial Pathogens and Usual Pattern of Susceptibility to Antibiotics (Anaerobes)
D. Preferred Therapy for Specific Bacterial and Mycobacterial Pathogens
4. Choosing Among Antibiotics Within a Class: Beta-lactams and Beta-lactamase Inhibitors, Macrolides, Aminoglycosides, and Fluoroquinolones
5. Preferred Therapy for Specific Fungal Pathogens A. Overview of More Common Fungal Pathogens and Their Usual Pattern of Antifungal SusceptibilitiesB. Systemic Infections
C. Localized Mucocutaneous Infections
6. Choosing Among Antifungal Agents: Polyenes, Azoles, and Echinocandins
7. Preferred Therapy for Specific Viral Pathogens A. Overview of Non-HIV, Non-hepatitis B or C Viral Pathogens and Usual Pattern of Susceptibility to Antivirals
B. Overview of Hepatitis B or C Viral Pathogens and Usual Pattern of Susceptibility to Antivirals
C. Preferred Therapy for Specific Viral Pathogens
8. Choosing Among Antiviral Agents
9. Preferred Therapy for Specific Parasitic Pathogens A. Selected Common Pathogenic Parasites and Suggested Agents for Treatment.
B. Preferred Therapy for Specific Parasitic Pathogens
10. Choosing Among Antiparasitic Agents: Antimalarial Drugs, Nitroimidazoles, Benzimidazoles, and Neglected Tropical Diseases
11. How Antibiotic Dosages Are Determined Using Susceptibility Data, Pharmacodynamics, and Treatment Outcomes
12. Approach to Antibiotic Therapy of Drug-Resistant Gram-negative Bacilli and Methicillin-Resistant Staphylococcus aureus
13. Antibiotic Therapy for Children Who Are Obese
14. Sequential Parenteral-Oral Antibiotic Therapy (Oral Step-down Therapy) for Serious Infections
15. Antimicrobial Prophylaxis/Prevention of Symptomatic Infection A. Postexposure Antimicrobial Prophylaxis to Prevent Infection
B. Long-term Antimicrobial Prophylaxis to Prevent Symptomatic New Infection
C. Prophylaxis of Symptomatic Disease in Children Who Have Asymptomatic Infection/Latent Infection
D. Surgical/Procedure Prophylaxis
16. Approach to Antibiotic Allergies
17. Antibiotic Stewardship
18. Systemic and Topical Antimicrobial Dosing and Dose Forms A. Systemic Antimicrobials With Dosage Forms and Usual Dosages
B. Topical Antimicrobials (Skin, Eye, Ear, Mucosa)
Appendix: Nomogram for Determining Body Surface Area
References
Index