Main description:

Adenosine A2A Receptor Antagonists, Volume 170 in the International Review of Neurobiology series highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including A2A Adenosine Receptor Agonists, Antagonists, Inverse Agonists and Partial Agonist, Chemistry - agonists, antagonists, partial agonists, inverse agonists, Functional roles of adenosine receptors - biochemistry and neuronal plasticity, A2A and Depression, A2AR and glial function, The adenosine A2A receptor in the basal ganglia: expression in health and disease, heteromerization, functional selectivity and signaling, How and why A2a receptor become to be a therapeutic target in Parkinson's disease therapy, and much more.

Contents:

1. A2A Adenosine Receptor Agonists, Antagonists, Inverse Agonists and Partial Agonists

2. Chemistry - agonists, antagonists, partial agonists, inverse agonists

3. Functional roles of adenosine receptors - biochemistry and neuronal plasticity

4. A2A and Depression

5. A2AR and glial function

6. The adenosine A2A receptor in the basal ganglia: expression in health and disease, heteromerization, functional selectivity and signalling

7. How and why A2a receptor become to be a therapeutic target in Parkinson's disease therapy

8. Development of A2a antagonists for Parkinson's disease - clinical evaluation for motor and non-motor symptoms

9. The role of A2AR in chemobrain and the potential therapeutic benefits of istradefylline

10. Effects of adenosine A2A receptors on cognitive function in health and disease

11. A2a receptor and Sleep disturbance

12. Adenosine A2A signals and Dystonia

13. Protective potential of caffeine and adenosine A2A adenosine receptor antagonism in LRRK2 Parkinson's disease

14. A2a antagonists and Alzheimer's disease

15. A2a receptors and ALS/MS

16. A2AR and trauma/PTSD