Main description:

This book explains about amino acids (AAs) which are not only building blocks of protein, but are also signaling molecules as well as regulators of gene expression and the protein phosphorylation cascade. Additionally, AAs are key precursors for syntheses of hormones and low-molecular-weight nitrogenous substances with each having enormous biological importance. For example, physiological concentrations of AA metabolites (e.g., nitric oxide, polyamines, glutathione, taurine, thyroid hormones, and serotonin) are required for cell functions. Growing evidence shows that humans and animals have dietary requirements for all proteinogenic AAs. Mammals, birds, and fish also have species- and age-dependent needs for some AA-related substances. However, elevated levels of other products (e.g., ammonia, homocysteine, H2S, and asymmetric dimethylarginine) are pathogenic factors for neurological disorders, oxidative stress, and cardiovascular disease. Thus, optimal amounts of AAs and their ratios in diets and circulation are crucial for whole-body homeostasis and health. Adequate provision of one or a mixture of functional AAs or metabolites may be beneficial for ameliorating health problems at various stages of the life cycle (e.g., fetal growth restriction, neonatal morbidity and mortality, weaning-associated intestinal dysfunction and wasting syndrome, obesity, diabetes, cardiovascular disease, the metabolic syndrome, and infertility). Dietary supplementation of these nutrients can also optimize the efficiency of metabolic transformations to enhance muscle growth, milk production, and athletic performance, while preventing excess fat deposition and reducing adiposity. Therefore, functional AAs hold great promise in improving the growth, health, and well-being of individuals.

Contents:

Chapter 1:

Regulation of Gene Expression by Amino Acids in Animal Cells.

Nirvay Sah, Guoyao Wu, and Fuller W. Bazer

Chapter 2:

Amino acids in cell signaling: regulation and function.

Sudikshya Paudel, Guoyao Wu, and Xiaoqiu Wang

Chapter 3:

Amino Acids in Endoplasmic Reticulum Stress and Redox Signaling.

Ying Yang, Yu He, Yuhang Jin, Guoyao Wu, and Zhenlong Wu

Chapter 4:

Amino Acids in Autophagy: Regulation and Function.

James Z. Shen, Guoyao Wu, and Shaodong Guo

Chapter 5:

Oxidation of Energy Substrates in Tissues of Fish: Metabolic Significance and Implications for Gene Expression and Carcinogenesis.

Sichao Jia, Xinyu Li, Wenliang He, and Guoyao Wu

Chapter 6:

Arginine, Agmatine and Polyamines: Key Regulators of Conceptus Development in Mammals.

Katherine M. Halloran, Claire Stenhouse, Guoyao Wu, and Fuller W. Bazer

Chapter 7:

Interorgan Metabolism of Glutamate and Glutamine in Poultry.

Wenliang He, Kyohei Furukawa, Masaaki Toyomizu, Tomonori Nochi, Christopher A. Bailey, and Guoyao Wu

Chapter 8:

Interorgan Metabolism of Amino Acids in Health and Disease.

Patrick Ryan, Steven E. Riechman, James D. Fluckey, and Guoyao Wu

Chapter 9:

Amino Acids and Their Metabolites for Improving Human Exercising Performance.

Erin A. Posey, Fuller W. Bazer, and Guoyao Wu

Chapter 10:

Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans.

Guoyao Wu, Cynthia J. Meininger, Catherine J. McNeal, Fuller W. Bazer, and J. Marc Rhoads

Chapter 11:

Composition of Amino Acids in Foodstuffs for Humans and Animals.

Peng Li, and Wenliang He, and Guoyao Wu

Chapter 12:

Dietary Intakes of Amino Acids and Other Nutrients by Adult Humans.

Tapasree R. Sarkar, Catherine J. McNeal, Cynthia J. Meininger, Yabo Niu, Bani K. Mallick, Raymond J. Carroll, and Guoyao Wu