Main description:

The development of treatment strategies that can help patients with spinal cord injury to regain lost functions and an improved quality of life is a major medical challenge, and experimental spinal cord research has to meet these challenges by resolving fundamental problems, establishing a basis for possible novel treatment strategies of spinal cord injury, and motivating their clinical translation. In Animal Models of Spinal Cord Repair, expert researchers examine a broad range of experimental models for research on spinal cord injury, how they have contributed to our current state of knowledge, and what their advantages are in the further advancement of spinal cord repair. With models from simple lamprey to non-human primates, the information presented is intended to guide the implementation of animal models for spinal cord repair as well as to raise the awareness of the relevance of experimental models which may not be in the current mainstream of this research. As a part of the Neuromethods series, this work contains the kind of detailed description and implementation advice to guarantee successful results in the laboratory.

Comprehensive and cutting-edge, Animal Models of Spinal Cord Repair presents the background information and hands-on methods descriptions, as well as the basic and clinical issues, needed to stimulate and guide researchers with different backgrounds towards the development of improved strategies for functionally relevant repair of the injured human spinal cord.

Contents:

1. The Spinal Cord: Functional Organization, Diseases, and Dysfunctions

Pierre A. Guertin

2. The Pathological Findings in Traumatic Injury to the Human Spinal Cord

Ronald C. Kim

3. Acute Spinal Cord Injury In Vitro: Insight Into Basic Mechanisms

Miranda Mladinic, Andrea Nistri, and Giuliano Taccola

4. Spinal Cord Injury: The Lamprey Model

Andrew D. McClellan

5. Dorsal Root Injury for the Study of Spinal Cord Injury Repair

Hakan Aldskogius and Elena N. Kozlova

6. No-Laminectomy Spinal Cord-Transected Murine Model

Pierre A. Guertin

7. Spinal Cord Injury: The Rabbit Model

Nadezda Lukacova

8. The Cat Model of Spinal Cord Injury

Alain Frigon

9. Using Naturally-Occurring Spinal Cord Injury in Domestic Dogs to Explore Novel Therapeutic Options

Nick D. Jeffery, Nicolas Granger, and Robin J.M. Franklin

10. Primate Models of Spinal Repair

Corinna Darian-Smith

11. Animal Models of Spinal Cord Ischemia

Hamdy Awad, Haytham Elgharably, and Phillip Popovich

12. Magnetic Resonance Imaging of Experimental Spinal Cord Injury

Laura E. Gonzalez-Lara, Freda Jawan, and Paula J. Foster

13. Spinal Cord Injuries: Principles and Methods for Outcome Assessment

Elisabet Akesson, Cinzia Calzarossa, and Erik Sundstroem

14. Spinal Cord Injury: Modern Clinical Management and Its Correlation to Advances in Basic Science

Anders Holtz, Leif Anderberg, Shala Ghaderi Berntsson, and Hakan Aldskogius

Pierre A. Guertin

2. The Pathological Findings in Traumatic Injury to the Human Spinal Cord

Ronald C. Kim

3. Acute Spinal Cord Injury In Vitro: Insight Into Basic Mechanisms

Miranda Mladinic, Andrea Nistri, and Giuliano Taccola

4. Spinal Cord Injury: The Lamprey Model

Andrew D. McClellan

5. Dorsal Root Injury for the Study of Spinal Cord Injury Repair

Hakan Aldskogius and Elena N. Kozlova

6. No-Laminectomy Spinal Cord-Transected Murine Model

Pierre A. Guertin

7. Spinal Cord Injury: The Rabbit Model

Nadezda Lukacova

8. The Cat Model of Spinal Cord Injury

Alain Frigon

9. Using Naturally-Occurring Spinal Cord Injury in Domestic Dogs to Explore Novel Therapeutic Options

Nick D. Jeffery, Nicolas Granger, and Robin J.M. Franklin

10. Primate Models of Spinal Repair

Corinna Darian-Smith

11. Animal Models of Spinal Cord Ischemia

Hamdy Awad, Haytham Elgharably, and Phillip Popovich

12. Magnetic Resonance Imaging of Experimental Spinal Cord Injury

Laura E. Gonzalez-Lara, Freda Jawan, and Paula J. Foster

13. Spinal Cord Injuries: Principles and Methods for Outcome Assessment

Elisabet Akesson, Cinzia Calzarossa, and Erik Sundstroem

14. Spinal Cord Injury: Modern Clinical Management and Its Correlation to Advances in Basic Science

Anders Holtz, Leif Anderberg, Shala Ghaderi Berntsson, and Hakan Aldskogius

Miranda Mladinic, Andrea Nistri, and Giuliano Taccola

4. Spinal Cord Injury: The Lamprey Model

Andrew D. McClellan

5. Dorsal Root Injury for the Study of Spinal Cord Injury Repair

Hakan Aldskogius and Elena N. Kozlova

6. No-Laminectomy Spinal Cord-Transected Murine Model

Pierre A. Guertin

7. Spinal Cord Injury: The Rabbit Model

Nadezda Lukacova

8. The Cat Model of Spinal Cord Injury

Alain Frigon

9. Using Naturally-Occurring Spinal Cord Injury in Domestic Dogs to Explore Novel Therapeutic Options

Nick D. Jeffery, Nicolas Granger, and Robin J.M. Franklin

10. Primate Models of Spinal Repair

Corinna Darian-Smith

11. Animal Models of Spinal Cord Ischemia

Hamdy Awad, Haytham Elgharably, and Phillip Popovich

12. Magnetic Resonance Imaging of Experimental Spinal Cord Injury

Laura E. Gonzalez-Lara, Freda Jawan, and Paula J. Foster

13. Spinal Cord Injuries: Principles and Methods for Outcome Assessment

Elisabet Akesson, Cinzia Calzarossa, and Erik Sundstroem

14. Spinal Cord Injury: Modern Clinical Management and Its Correlation to Advances in Basic Science

Anders Holtz, Leif Anderberg, Shala Ghaderi Berntsson, and Hakan Aldskogius

Pierre A. Guertin

7. Spinal Cord Injury: The Rabbit Model

Nadezda Lukacova

8. The Cat Model of Spinal Cord Injury

Alain Frigon

9. Using Naturally-Occurring Spinal Cord Injury in Domestic Dogs to Explore Novel Therapeutic Options

Nick D. Jeffery, Nicolas Granger, and Robin J.M. Franklin

10. Primate Models of Spinal Repair

Corinna Darian-Smith

11. Animal Models of Spinal Cord Ischemia

Hamdy Awad, Haytham Elgharably, and Phillip Popovich

12. Magnetic Resonance Imaging of Experimental Spinal Cord Injury

Laura E. Gonzalez-Lara, Freda Jawan, and Paula J. Foster

13. Spinal Cord Injuries: Principles and Methods for Outcome Assessment

Elisabet Akesson, Cinzia Calzarossa, and Erik Sundstroem

14. Spinal Cord Injury: Modern Clinical Management and Its Correlation to Advances in Basic Science

Anders Holtz, Leif Anderberg, Shala Ghaderi Berntsson, and Hakan Aldskogius

Nadezda Lukacova

8. The Cat Model of Spinal Cord Injury

Alain Frigon

9. Using Naturally-Occurring Spinal Cord Injury in Domestic Dogs to Explore Novel Therapeutic Options

Nick D. Jeffery, Nicolas Granger, and Robin J.M. Franklin

10. Primate Models of Spinal Repair

Corinna Darian-Smith

11. Animal Models of Spinal Cord Ischemia

Hamdy Awad, Haytham Elgharably, and Phillip Popovich

12. Magnetic Resonance Imaging of Experimental Spinal Cord Injury

Laura E. Gonzalez-Lara, Freda Jawan, and Paula J. Foster

13. Spinal Cord Injuries: Principles and Methods for Outcome Assessment

Elisabet Akesson, Cinzia Calzarossa, and Erik Sundstroem

14. Spinal Cord Injury: Modern Clinical Management and Its Correlation to Advances in Basic Science

Anders Holtz, Leif Anderberg, Shala Ghaderi Berntsson, and Hakan Aldskogius

Alain Frigon

9. Using Naturally-Occurring Spinal Cord Injury in Domestic Dogs to Explore Novel Therapeutic Options

Nick D. Jeffery, Nicolas Granger, and Robin J.M. Franklin

10. Primate Models of Spinal Repair

Corinna Darian-Smith

11. Animal Models of Spinal Cord Ischemia

Hamdy Awad, Haytham Elgharably, and Phillip Popovich

12. Magnetic Resonance Imaging of Experimental Spinal Cord Injury

Laura E. Gonzalez-Lara, Freda Jawan, and Paula J. Foster

13. Spinal Cord Injuries: Principles and Methods for Outcome Assessment

Elisabet Akesson, Cinzia Calzarossa, and Erik Sundstroem

14. Spinal Cord Injury: Modern Clinical Management and Its Correlation to Advances in Basic Science

Anders Holtz, Leif Anderberg, Shala Ghaderi Berntsson, and Hakan Aldskogius

Nick D. Jeffery, Nicolas Granger, and Robin J.M. Franklin

10. Primate Models of Spinal Repair

Corinna Darian-Smith

11. Animal Models of Spinal Cord Ischemia

Hamdy Awad, Haytham Elgharably, and Phillip Popovich

12. Magnetic Resonance Imaging of Experimental Spinal Cord Injury

Laura E. Gonzalez-Lara, Freda Jawan, and Paula J. Foster

13. Spinal Cord Injuries: Principles and Methods for Outcome Assessment

Elisabet Akesson, Cinzia Calzarossa, and Erik Sundstroem

14. Spinal Cord Injury: Modern Clinical Management and Its Correlation to Advances in Basic Science

Anders Holtz, Leif Anderberg, Shala Ghaderi Berntsson, and Hakan Aldskogius

Corinna Darian-Smith

11. Animal Models of Spinal Cord Ischemia

Hamdy Awad, Haytham Elgharably, and Phillip Popovich

12. Magnetic Resonance Imaging of Experimental Spinal Cord Injury

Laura E. Gonzalez-Lara, Freda Jawan, and Paula J. Foster

13. Spinal Cord Injuries: Principles and Methods for Outcome Assessment

Elisabet Akesson, Cinzia Calzarossa, and Erik Sundstroem

14. Spinal Cord Injury: Modern Clinical Management and Its Correlation to Advances in Basic Science

Anders Holtz, Leif Anderberg, Shala Ghaderi Berntsson, and Hakan Aldskogius

Hamdy Awad, Haytham Elgharably, and Phillip Popovich

12. Magnetic Resonance Imaging of Experimental Spinal Cord Injury

Laura E. Gonzalez-Lara, Freda Jawan, and Paula J. Foster

13. Spinal Cord Injuries: Principles and Methods for Outcome Assessment

Elisabet Akesson, Cinzia Calzarossa, and Erik Sundstroem

14. Spinal Cord Injury: Modern Clinical Management and Its Correlation to Advances in Basic Science

Anders Holtz, Leif Anderberg, Shala Ghaderi Berntsson, and Hakan Aldskogius

Laura E. Gonzalez-Lara, Freda Jawan, and Paula J. Foster

13. Spinal Cord Injuries: Principles and Methods for Outcome Assessment

Elisabet Akesson, Cinzia Calzarossa, and Erik Sundstroem

14. Spinal Cord Injury: Modern Clinical Management and Its Correlation to Advances in Basic Science

Anders Holtz, Leif Anderberg, Shala Ghaderi Berntsson, and Hakan Aldskogius

Elisabet Akesson, Cinzia Calzarossa, and Erik Sundstroem

14. Spinal Cord Injury: Modern Clinical Management and Its Correlation to Advances in Basic Science

Anders Holtz, Leif Anderberg, Shala Ghaderi Berntsson, and Hakan Aldskogius

Anders Holtz, Leif Anderberg, Shala Ghaderi Berntsson, and Hakan Aldskogius