Main description:

This book is quick guide on the hematopoietic stem cell transplant (SCT), also called bone marrow transplant (BMT) - an evolving field of hematology and hemato-oncology. This book covers the various types of stem cell transplants like autologous and allogeneic stem cell transplants, indications, ways of doing a transplant, and stem cell transplants basic principles. Written in a question-answer format, readers will find it more interesting as one question sequentially leads to another. This book explains the complications of SCT in individual chapters along with the biology of T cells which are the most important cells involved in the success of SCT

This book is beneficial to the budding hematologists, oncologists, and postgraduates interested in SCT and helps students in their exams. The book would be helpful for readers globally as SCT is a procedure done worldwide and is an ever-increasing field for treating various benign and malignant hematological diseases.

Contents:

TABLE OF CONTENTS

SECTION 1: INTRODUCTION TO BASICS OF T CELLS AND STEM CELL TRANSPLANT

1. HISTORY OF STEM CELL TRANSPLANT

2. BASICS OF STEM CELL TRANSPLANT

3. STEM CELL MICROENVIRONMENT

4. HEMATOPOIESIS

5. T CELL DEVELOPMENT-1

6. T CELL DEVELOPMENT-2

7. ROLE OF THYMUS

8. IMMUNOLOGY OF STEM CELL TRANSPLANT

9. EARLY T PRECURSOR CELL

10. REGULATORY T CELLS

11. TOLERANCE INDUCTION

SECTION 2: DISEASES OF T CELLS AND STEM CELLS

12. T CELL DEFECTS AND DISEASES

13. INDICATIONS FOR STEM CELL TRANSPLANT

SECTION 3: PRETRANSPLANT PROCEDURES

14. MAJOR HISTOCOMPATIBILITY COMPLEX

15. APHERESIS

16. CRYOPRESERVATION

SECTION 4: RADIO-CHEMOTHERAPEUTIC AGENTS USED IN STEM CELL TRANSPLANT

17. CLASSIFICATION OF CONDITIONING REGIMENS

18. CHEMOTHERAPEUTIC AGENTS

19. ROLE OF ANTI THYMOCYTE GLOBULIN IN STEM CELL TRANSPLANT

20. TOTAL BODY IRRADIATION

SECTION 4: AUTOLOGOUS STEM CELL TRANSPLANT

21. INDICATIONS FOR AUTOLOGOUS STEM CELL TRANSPLANT

22. STEM CELL TRANSPLANT FOR AUTOIMMUNE DISEASES

23. STEM CELL TRANSPLANT FOR HODGKIN LYMPHOMA

24. STEM CELL TRANSPLANT FOR NON HODGKIN LYMPHOMA

25. STEM CELL TRANSPLANT FOR MULTIPLE MYELOMA

SECTION 5: ALLOGENEIC STEM CELL TRANSPLANT

26. STEM CELL TRANSPLANT FOR PRIMARY IMMUNODEFICIENCY DISEASES

27. STEM CELL TRANSPLANT FOR SEVERE APLASTIC ANEMIA

28. STEM CELL TRANSPLANT FOR HEMOGLOBINOPATHIES

29. STEM CELL TRANSPLANT FOR ACUTE LYMPHOBLASTIC LEUKEMIA

30. STEM CELL TRANSPLANT FOR ACUTE MYELOBLASTIC LEUKEMIA

31. STEM CELL TRANSPLANT FOR MYELOFIBROSIS

SECTION 5: HAPLOIDENTICAL STEM CELL TRANSPLANT

32. HAPLOIDENTICAL STEM CELL TRANSPLANT

SECTION 6: GVHD

33. ACUTE GVHD

34. CHRONIC GVHD

SECTION 7: POST TRANSPLANT MONITORING AND MANAGEMENT

35. IMMUNE RECONSTITUTION FOLLOWING STEM CELL TRANSPLANT

36. DRUGS USED POST STEM CELL TRANSPLANT

37. CHIMERISM

38. POST TRANSPLANT IMMUNOSUPPRESSION

39. DONOR LYMPHOCYTE INFUSION

40. ADOPTIVE T CELL THERAPY

SECTION 8: INFECTIONS POST STEM CELL TRANSPLANT

41. BACTERIAL INFECTIONS

42. CLOSTRIDIUM DIFFICILE

43. CYTOMEGALOVIRUS

44. FUNGAL INFECTIONS

45. VIRAL INFECTIONS

46. PNEUMOCYSTIS JIROVECII

SECTION 9: POST TRANSPLANT COMPLICATIONS

47. COMPLICATIONS POST STEM CELL TRANSPLANT

48. ENGRAFTMENT SYNDROME

49. HEMORRHAGIC CYSTITIS

50. SINUSOIDAL OBSTRUCTION SYNDROME

51. RELAPSE FOLLOWING ALLOGENEIC STEM CELL TRANSPLANT

52. BLOOD GROUP INCOMPATIBILITIES AND AFFECT ON TRANSPLANT

53. CYTOPENIAS POST STEM CELL TRANSPLANT

SECTION 10: MISCELLANEOUS

54. MISCELLANEOUS