Main description:

"Meningiomas are tumors that originate from the arachnoidal cap cells of the leptomeninges. With an incidence rate of 8.36 per 100, 000 population, they are the most common primary central nervous system (CNS) tumors, accounting for a third of all cases. The World Health Organization (WHO) classification has traditionally categorized meningiomas into 15 different histopathological subtypes and three clinical grades. Tumors are classified as WHO grades 1, 2 or 3 based largely on histopathological features such as mitotic activity, presence of brain invasion, and other atypical features. However, there is increasing recognition of the limitations of histopathology including but not limited to: confounding factors such as sampling bias in a heterogeneous tumor, and technical factors related to the experience of the grading pathologist. Even with careful histologic grading, there remains significant variability in recurrence rates within each tumor grade. As more studies have uncovered the molecular features of meningiomas, novel biological alterations have helped refine classification schemes that more accurately reflect patient outcomes. This book reviews the current state of knowledge on the genomic and epigenomic landscape of meningiomas in order to identify the roles of genomic aberrations on diagnosis, prognosis, and treatment of meningiomas in addition to mainstays of surgical management, radiation therapy, and potential novel chemotherapies. Written by a team of world-renowned experts in neurosurgery, neuropathology, radiology, and radiation-oncology, this book is the definitive resource on meningioma management and investigation for both clinicians and scientists alike."

Contents:

Chapter 1: Introduction and History of Meningiomas

Contributor: Dr. David Louis

Chapter 2: Clinical Presentation and Prognosis

Contributors: Drs. Ghazeleh Tabatabai and Marcos Tatagiba

Chapter 3: Imaging Characteristics of Meningiomas

Contributors: Drs. Timothy Kaufmann, Joerg Christian-Tonn, Christian Lafougere

Chapter 4: Histopathology of Meningiomas

Contributors: Drs. Andreas von Deimling and Arie Perry

Chapter 5: Skull Base Meningiomas

Contributors: Drs. Marcos Tatagiba and Manfred Westphal

Chapter 6: Spinal Meningiomas

Contributors: Dr. Michael Fehlings

Chapter 7: Surgical Therapies

Contributors: Drs. Marcos Tatagiba and Joerg Christian-Tonn

Chapter 8: Radiation Therapies

Contributors: Drs. Leland Rogers and Minesh Meh

Chapter 9: Illustrative Cases

Chapter 10: Advances in CNS Tumor Classification

Contributors: Drs. Felix Sahm and Houtan Noushmehr

Chapter 11: Genomic Landscape

Contributors: Dr. Gelareh Zadeh and Ken Aldape

Chapter 12: Radiation-Induced Meningiomas

Contributors: Dr. Gelareh Zadeh and Suganth Suppiah

Chapter 13: Meningioma Predisposing Syndromes

Contributors: Drs. Ghazeleh Tabatabi and Marcos Tatagiba

Chapter 14: Epigenetic Landscape

Contributors: Drs. Ken Aldape and Farshad Nassiri

Chapter 15: Immune Profile

Contributors: Drs. David Reardon and Ian Dunn

Chapter 16: PDX Models/Mouse Models/Cell lines

Contributors: Drs. Craig Horbinski, Michele Kalamarides, David James

Chapter 17: Novel Medical Therapies

Contributors: Drs. Priscilla Brastianos and Patrick Wen

Chapter 18: Quality of Life in Meningioma Patients

Contributors: Dr. Michael Cusimano and Michael McDermott

Chapter 19: Illustrative Cases: Revisited with Adjuvant Molecular Data

Chapter 20: Future Directions in Management

Contributors: Dr. Gelareh Zadeh and Ken Aldape