Main description:

This book provides a concise update on current understanding of the biology of acute and chronic leukemias and other bone marrow neoplasms, including myelodysplastic and myeloproliferative disorders, and explores new and emerging treatments. There is a particular focus on the molecular abnormalities that are drivers of leukemia and on their detection by modern molecular techniques. Knowledge of the ways in which genomic and metabolic abnormalities in the hematologic neoplasms affect prognosis and treatment decision making is reviewed. Detailed attention is devoted to targeted therapies, including novel drugs, and to potential targets for future drug development. In addition, readers find in-depth discussion of cellular and antibody-based immunotherapies as well as the role of hematopoietic stem cell transplantation in the treatment of leukemias and bone marrow malignancies. The book is of special interest for hematologists, oncologists, and cancer researchers; it is also of value for hematology trainees and medical students.

Contents:

1. Advances in diagnosis and risk stratification of leukemias and bone marrow neoplasms. Raju Pillai, Michelle Afkhami2. Genetics and diagnostic approach to lymphoblastic leukemia. Michelle Afkami, Feras Ally, Raju Pillai3. Acute promyelocytic leukemia: update on risk stratification and treatment. Amandeep Salhotra, Matthew Mei4. Current and emerging therapies for AML. Brian Ball, A Aribi, Matthew Mei, Salman Otukesh, A Stein, G Marcucci5. Current management and new developments in treatment of ALL. Justin Darrah, Weili Sun. 6. Contemporary therapy of CML. David Snyder.7. MDS: Pathogenesis and therapy. Ryotaro Nakamura, Samer Khaled, Shukaib Arslan. 8. Chronic lymphocytic leukemia: Biology and therapy. Tanya Siddiqi, Steve Rosen, 9. Biology and current treatment of Myeloproliferative neoplasms. Haris Ali, David Snyder. 10. Systemic Mastocytosis: Pathology and treatment. Sheeja Pullarkat, Winnie Wu, Vinod Pullarkat, 11. Adoptive T-cell therapy and other novel immunotherapies for leukemia. Geoffrey Shouse, Elizabeth Budde, Stephen Forman.