Main description:

This book collects and reviews, for the first time, a wide range of advances in the area of human aging biomarkers. This accumulated data allows researchers to assess the rate of aging processes in various organs and systems, and to individually monitor the effectiveness of therapies intended to slow aging.

In an introductory chapter, the editor defines biomarkers of aging as molecular, cellular and physiological parameters that demonstrate reproducible changes - quantitative or qualitative - with age. The introduction recounts a study which aimed to create a universal model of biological age, whose most predictive parameters were albumin and alkaline phosphatase (indication liver function), glucose (metabolic syndrome), erythrocytes (respiratory function) and urea (renal function).

The book goes on to describe DNA methylation, known as the "epigenetic clock," as currently the most comprehensive predictor of total mortality. It is also useful for predicting mortality from cancer and cardiovascular diseases, and for analyzing the effects of lifestyle factors including diet, exercise, and education.

Individual contributions draw additional insight from research on genetics and epigenetic aging markers, and immunosenescence and inflammaging markers. A concluding chapter outlines the challenge of integrating of biological and clinical markers of aging.

Biomarkers of Human Aging is written for professionals and practitioners engaged in the study of aging, and will be useful to both advanced students and researchers.

Contents:

Chapter 1: Introduction - Alexey Moskalev

Section-1: BIOMARKERS OF AGING AND HEALTH

Chapter 2: Practical Detection of Biological Age: Why it is not a trivial task - Ancha Baranova Tiange Cui, Boris Veytsman

Chapter 3: Biological age is a universal marker of aging, stress, and frailty - Timothy V. Pyrkov, Peter O. Fedichev

Chapter 4: Biomarkers of health and healthy ageing from the outside-in - Jonathan Sholl , Suresh Rattan

Chapter 5: Biomarkers of aging - Yizhen Yan, Yonglin Mu, Weiyang Chen, Jing-Dong J. Han

Chapter 6: Review of molecular and cellular biomarkers of aging - Ilya Solovyev, Mikhail Shaposhnikov, Alexey Moskalev

Section-2: PROTEOMICS AND GLYCOMICS BIOMARKERS OF AGING

Chapter 7: IgG glycans as a biomarker of biological age - Vilaj M, Gudelj I, Trbojevic-Akmacic I, Lauc G, Pezer M

Chapter 8: Oxidatively modified proteins and maintenance systems as biomarkers of aging - Bertrand Friguet, Martin Baraibar

Chapter 9: Is impaired proteodynamics a key to understand the biomarkers of cellular aging? - Jacek M. Witkowski ,Tamas Fulop

Section-3: GENETICS AND EPIGENETICS AGING MARKERS

Chapter 10: Genetic markers of extreme human longevity - Paola Sebastiani, Anastasia Gurinovich, Harold Bae, Thomas T Perls

Chapter 11: Epigenetic biomarkers of aging - Morgan E. Levine

Chapter 12: DNA methylation biomarkers to assess biological age -Dmitiriy Podolskiy, Vadim Gladyshev

Chapter 13: Epigenetics of brain aging: lessons from chemo brain and tumor brain - Anna Kovalchuk, Bryan Kolb, Olga Kovalchuk

Chapter 14: Approaches and methods for variant analysis in a cell - Alexej Abyzov, Flora M. Vaccarino, Alexander E. Urban, Vivekananda Sarangi

Section-4: IMMUNOSENESCENCE AND INFLAMMAGING MARKERS

Chapter 15: Is there any reliable biomarker for immunosenescence and inflammaging? - Tamas Fulop, Alan Cohen, Glenn Wong, Jacek M Witkowski, Anis Larbi.

Chapter 16: Immune parameters associated with mortality in longitudinal studies of very old people can be markedly dissimilar even in apparently similar populations - Graham Pawelec, David Goldeck

Chapter 17: Gut microbiota and aging - Kashtanova DA, Tkacheva ON, Strazhesko ID, Dudinskaya EN, Kotovskaya YuV, Popenko AS, Tyaht AV, Alexeev DG

Section-5: SYSTEMS BIOLOGY OF AGING, BIOLOGICAL AGE AND MORTALITY MARKERS

Chapter 18: Deep integrated biomarkers of aging - Polina Mamoshina, Alex Zhavoronkov

Chapter 19: Quantification of the biological age of the brain using neuroimaging - James Cole, Katja Franke , Nic Cherbuin

Chapter 20: Arterial aging: the role of hormonal and metabolic status and telomere biology - Irina D. Strazhesko , Daria A. Kashtanova, Ekaterina N. Dudinskaya, Olga N. Tkacheva

Chapter 21: Circulating Biomarkers of Aging - Hongxia Zhang, Brian Wang, Kunlin Jin

Chapter 22: Molecular signature of aging driven by Wnt signaling pathway: Lessons from nematodes - Marco Lezzerini, Yelena V. Budovskaya.

Chapter 23: The problem of integrating of biological and clinical markers of aging - Arnold Mitnitski

Index