Main description:

The underlying mechanisms of Candida and candidiasis and promising new directions in drug discovery and treatment.

Reviews all aspects of this common fungal pathogen and its impact on human health, from the basic biology of Candida albicans to the clinical management of candidiasis.
Reviews the latest basic and clinical research, focusing on findings in genome variability, host-pathogen interactions, antifungal resistance and drug discovery, and diagnostics to foster better understanding and treatment of candidiasis.
Examines recent discoveries that have shed light on morphogenesis and the cell cycle, including how new findings on host responses may have applications for the diagnosis of blood-borne candidiasis.

This title is published by the American Society of Microbiology Press and distributed by Taylor and Francis in rest of world territories.

Contents:

Table of Contents

Contributors
Preface

1 Candida: What Should Clinicians and Scientists Be Talking About?
Brad Spellberg, Kieren A. Marr, and Scott G. Filler

SECTION I: The Organisms, Their Genomics, and Variability

2 An Introduction to the Medically Important Candida Species
Gary Moran, David Coleman, and Derek Sullivan

3 Comparative Genomics of Candida Species
Geraldine Butler

4 The Genetic Code of the Candida CTG Clade
Ana Catarina Gomes, Gabriela R. Moura, and Manuel A. S. Santos

5 Genome Instability and DNA Repair
German Larriba and Richard A. Calderone

6 Switching and Mating
David R. Soll

7 Detection and Clinical Significance of Variability among Candida Isolates
Lois L. Hoyer

8 Cell Cycle and Growth Control in Candida Species
Cheryl A. Gale and Judith Berman

SECTION II: Host-Pathogen Interactions (The Host)

9 Immunology of Invasive Candidiasis
Luigina Romani

10 Mucosal Immunity to Candida albicans
Paul L. Fidel, Jr., and Mairi C. Noverr

11 Innate Immunity to Candida Infections
Mihai G. Netea and Neil A. R. Gow

12 Vaccines and Passive Immunity against Candidiasis
rad Spellberg, Yue Fu, and Ashraf S. Ibrahim

13 Salivary Histatins: Structure, Function, and Mechanisms of Antifungal Activity
Woon Sik Jang and Mira Edgerton

SECTION III: Host-Pathogen Interactions (The Pathogen)

14 The Cell Wall: Glycoproteins, Remodeling, and Regulation
Carol Munro and Mathias L. Richard

15 Stress Responses in Candida
Alistair J. P. Brown, Ken Haynes, Neil A. R. Gow, and Janet Quinn

16 Adhesins in Opportunistic Fungal Pathogens
Rebecca Zordan and Brendan Cormack

17 Encounters with Mammalian Cells: Survival Strategies of Candida Species
Slavena Vylkova and Michael C. Lorenz

18 Gene Expression during the Distinct Stages of Candidiasis
Duncan Wilson, Francois Mayer, and Bernhard Hube

19 Biofilm Formation in Candida albicans
Jonathan Sewell Finkel and Aaron P. Mitchell

20 Candida spp. in Microbial Populations and Communities: Molecular Interactions and Biological Importance
Amy E. Piispanen and Deborah A. Hogan

21 Back to the Future: Candida Mitochondria and Energetics
Deepu Alex, Richard Calderone, and Dongmei Lee

SECTION IV: Antifungal Drugs, Drug Resistance, and Discovery

22 Antifungals: Drug Class, Mechanisms of Action, Pharmacokinetics/Pharmacodynamics, Drug-Drug Interactions, Toxicity, and Clinical Use
Jeniel E. Nett and David R. Andes

23 The Impact of Antifungal Drug Resistance in the Clinic
Russell E. Lewis and Dimitrios P. Kontoyiannis

24 Insights in Antifungal Drug Discovery
Francoise Gay-Andrieu, Jared May, Dongmei Li, Nuo Sun, Hui Chen, Richard Calderone, and Deepu Alex

25 Multidrug Resistance Transcriptional Regulatory Networks in Candida
P. David Rogers and Katherine S. Barker

SECTION V: Candidiasis, Evolving Diagnostics, and Treatment Paradigms

26 Mucosal Candidiasis
Sanjay Revankar and Jack D. Sobel

27 Systemic Candidiasis: Candidemia and Deep-Organ Infections
Cornelius J. Clancy and M. Hong Nguyen

28 New Developments in Diagnostics and Management of Invasive Candidiasis
Sujatha Krishnan and Luis Ostrosky-Zeichner

29 The Epidemiology of Invasive Candidiasis
Michael A. Pfaller and Daniel J. Diekema

SECTION VI: Cool Tools for Research

30 Cool Tools 1: Development and Application of a Candida albicans Two-Hybrid System
Bram Stynen, Patrick Van Dijck, and Helene Tournu

31 Cool Tools 2: Development of a Candida albicans Cell Surface Protein Microarray
A. Brian Mochon

32 Cool Tools 3: Large-Scale Genetic Interaction Screening in Candida albicans
Yeissa Chabrier-Rosello, Anuj Kumar, and Damian Krysan

33 Cool Tools 4: Imaging Candida Infections in the Live Host
Soumya Mitra, Thomas H. Foster, and Melanie Wellington

34 Cool Tools 5: The Candida albicans ORFeome Project
Melanie Legrand, Carol Munro, and Christophe d'Enfert
Index