Main description:

This contributed volume focuses on cardiovascular diseases (CVDs), and explores the ways in which signaling mechanisms at the biochemical, molecular, and cellular levels in the blood vessels (vascular) and heart contribute to the underlying causes of development and progression of the CVDs. This volume covers unique topics such as oxidant signaling in vascular and heart diseases and health, cytoskeletal signaling in vascular health and disease, phospholipase signaling in CVDs, lipid signaling in vascular and myocardial health and diseases, and drug discovery in cellular signaling for cardiovascular diseases.

This book assembles the most important discoveries made by leaders on the cellular signaling mechanisms operating behind the development and progression of life-threatening CVDs. It is an extremely useful resource for the investigators in the field of CVDs, and opens the discussion for further discovery of efficient management and effective treatment of the CVDs.

Contents:

Table of contents

Preface on the Current Trends in Cardiovascular Signaling in Health and Disease

Narasimham L. Parinandi and Thomas J. Hund

Department of Internal Medicine and Department of Biomedical Engineering, The Ohio State University Wexner Medical Center, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA

Part 1: Cardiac Signaling

Chapter 1: Calcium-Dependent Signaling in Cardiac Myocytes

Christopher Y. Ko, Charlotte E. R. Smith, Eleonora Grandi

Department of Pharmacology, University of California Davis, Davis, CA, USA

Chapter 2: Organization of Ca2+ Signaling Microdomains in Cardiac Myocytes

Jing Li, Bradley Richmond, and TingTing Hong

Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA

Chapter 3: Stress Kinase Signaling in Cardiac Myocytes

Xun Ai, Jiajie Yan, Dan Bare

Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA

Chapter 4: Cardiotoxicity and cardiac cell signaling

Shane Scott and Sakima Smith

Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA

Chapter 5: Protein Phosphatase Signaling in Cardiac Myocytes

Danielle Abdallah, Nipun Malhotra, and Mona El Refaey

Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA

Chapter 6: Metabolic Regulation of Mitochondrial Dynamics and Cardiac Function

Michael W. Rudokas, Marine Cacheux, and Fadi G. Akar

Cardiovascular Research Center, Yale University, New Haven, CT, USA

Chapter 7: NADPH Oxidase System Mediates Cholesterol Secoaldehyde-Induced Oxidative Stress and Cytotoxicity in H9c2 Cardiomyocytes

Laura Laynes, Achuthan C. Raghavamenon, Deidra S. Atkins-Ball, and Rao M. Uppu

Department of Environmental Toxicology, Southern University and A&M College, Baton Rouge, LA, USA

Chapter 8: Lipid Mediators in Cardiovascular Physiology and Disease

Diego Hernandez-Saavedra and Kristin I. Stanford

Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA

Chapter 9: Cardiac Inflammasome and Arrhythmia

Na Li and Dobromir Dobrev

Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.

Chapter 10: Myocardial Fibrosis: Cell Signaling and In Vitro Modeling

Caleb Graham and Palaniappan Sethu

Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, USA

Chapter 11: Neural regulation of cardiac rhythm

Crystal M. Ripplinger

Department of Pharmacology, University of California Davis, Davis, CA, USA

Part 2: Vascular Signaling

Chapter 12: Mechanisms of lipoproteins and reverse cholesterol transport in atherosclerotic cardiovascular disease

Holly C. Sucharski and Sara N. Koenig

Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA

Chapter 13: Atherosclerotic plaque regression: Future perspective

Indu M. Suseela, Jose Padikkala, Thekkekara D. Babu, Rao M Uppu and Achuthan C. Raghavamenon

Department of Environmental Toxicology, Southern University and A&M College, Baton Rouge, LA, USA

Chapter 14: Role of Bioactive Lipid, Phosphatidic Acid in Hypercholesterolemia Drug-induced Myotoxicity - Statin-induced Phospholipase D (PLD) Lipid Signaling in Skeletal Muscle Cells

Eric M. Tretter, Patrick J. Oliver, Sainath R. Kotha, Travis O. Gurney, Drew M. Nassal, Thomas J. Hund, Narasimham L. Parinandi

Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA

Chapter 15: Cell-Cell Communication in the Vascular Endothelium

D. Ryan King, Louisa Mezache, Megan Sedovy, Przemyslaw B. Radwanski, Scott R. Johnstone, and Rengasayee Veeraraghavan

Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA

Chapter 16: Lysophosphatidic acid regulates endothelial barrier integrity

Jing Zhao, Sarah J. Taleb, Heather Huang, Yutong Zhao

Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA

Chapter 17: Regulation of Vascular Endothelial Barrier Integrity and Function by Lipid-Derived Mediators

Panfeng Fu, Ramaswamy Ramchandran, Steven M Dudek, Narasimham L Parinandi and Viswanathan Natarajan

University of Illinois at Chicago, Chicago, IL, USA

Chapter 18: Hyperglycemic Oxoaldehyde (Glyoxal)-induced Vascular Endothelial Cell Damage through Oxidative Stress is protected by Thiol Iron Chelator, Dimercaptosuccinic Acid - Role of Iron in Diabetic Vascular Endothelial Dysfunction

Travis O. Gurney, Patrick J. Oliver, Sean M. Sliman, Anita Yenigalla, Timothy D. Eubank, Drew M. Nassal, Jiaxing Miao, Jing Zhao, Thomas J. Hund, Narasimham L. Parinandi

Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA