Main description:

Accessible and user-friendly, Cell Biology, 4th Edition, provides a strong foundation for students entering health care career paths as well as higher level research areas. Clear, readable text and high-quality, detailed illustrations help readers quickly grasp challenging content-all focusing on cellular processes without delving into molecular processes. Drs. Thomas D. Pollard, William C. Earnshaw, Jennifer Lippincott-Schwartz, and author/illustrator Dr. Graham Johnson have thoroughly updated this popular text to ensure its relevance for students in biology, biotechnology, medicine, and pathophysiology, covering key principles of cellular function and explaining how molecular defects lead to cellular dysfunction and cause human disease.

Clear, readable explanations provide a concise story about how cells function at the molecular level.

An intuitive chapter flow starts with genome organization, gene expression, and RNA processing as a foundation for understanding every aspect of cellular function and physiology.

Brings cellular biology to life for students interested in medical science by explaining how mutations in genes can compromise virtually every cellular system and predispose to human disease. Knowledge of cell biology has led to new treatments for cancer, heart failure, cystic fibrosis, and many other diseases.

Unique illustrations with realistic proportions and relationships explain every cellular process including the assembly of SARS CoV-2, the structures attaching mitotic chromosomes to microtubules, the mechanism of DNA replication and how pumps, carriers and channels orchestrate physiological processes from synaptic transmission to cellular volume regulation.

Covers exciting breakthroughs such as SMC motor proteins actively organizing chromosomal DNA, TOR kinases regulating metabolism, new types of immunotherapy for cancer treatment, mechanisms regulating fast axonal transport and their relation to neurodegenerative diseases, how completion of DNA replication sets the time for cells to enter mitosis, how a cascade of signals specifies the site of cell division, and newly understood pathways of normal and pathological cell death.

Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Contents:

Section I Introduction to Cell Biology
1.Introduction to Cells
2.Evolution of Life on Earth

Section II Chemical and Physical Background
3.Molecules: Structures and Dynamics
4.Biophysical Principles
5.Macromolecular Assembly
6.Research Strategies

Section III Chromatin, Chromosomes, and the Cell Nucleus
7.Chromosome Organization
8.DNA Packaging in Chromatin and Chromosomes
9.Nuclear Structure and Dynamics

Section IV Central Dogma: From Gene to Protein
10.Gene Expression
11.Eukaryotic RNA Processing
12.Protein Synthesis and Folding

Section V Membrane Structure and Function
13.Membrane Structure and Dynamics
14.Membrane Pumps
15.Membrane Carriers
16.Membrane Channels
17.Membrane Physiology

Section VI Cellular Organelles and Membrane Trafficking
18.Posttranslational Targeting of Proteins
19.Mitochondria, Chloroplasts, Peroxisomes
20.Endoplasmic Reticulum
21.Secretory Membrane System and Golgi Apparatus
22.Endocytosis and the Endosomal Membrane System
23.Processing and Degradation of Cellular Components

Section VII Signaling Mechanisms
24.Plasma Membrane Receptors
25.Protein Hardware for Signaling
26.Second Messengers
27.Integration of Signals

Section VIII Cellular Adhesion and the Extracellular Matrix
28.Cells of the Extracellular Matrix and Immune System

29.Extracellular Matrix Molecules
30.Cellular Adhesion
31.Intercellular Junctions
32.Connective Tissues

Section IX Cytoskeleton and Cellular Motility
33.Actin and Actin-Binding Proteins
34.Microtubules and Centrosomes
35.Intermediate Filaments
36.Motor Proteins
37.Intracellular Motility
38.Cellular Motility
39.Muscles

Section X Cell Cycle
40.Introduction to the Cell Cycle
41.G1 Phase and Regulation of Cell Proliferation
42.S Phase and DNA Replication
43.G2 Phase, Responses to DNA Damage, and Control of Entry Into Mitosis
44.Mitosis and Cytokinesis
45.Meiosis
46.Programmed Cell Death
Appendix

Cell SnapShots