Main description:

This contributed volume is dedicated towards the progress achieved within the last years in all areas of Cell Culture Engineering and Technology. It comprises contributions of active researchers in the field of cell culture development for the production of recombinant proteins, cell line development, cell therapy and gene therapy, with consideration of media development, process scale-up, reactor design, monitoring and control and model-assisted strategies for process design. The knowledge and expertise of the authors cover disciplines like cell biology, engineering, biotechnology and biomedical sciences.

This book is conceived for graduate students, postdoctoral fellows and researchers interested in the latest developments in Cell Engineering.

Contents:

Contents
Preface
Part I: Cell Engineering, novel technologies and the use of omics
1 Biopharmaceuticals Produced from Cultivated Mammalian CellsRasoul Al-Majmaie, Darrin Kuystermans, Mohamed Al-Rubeai
2 Remote Control of Mammalian Therapeutic Designer CellsMaysam Mansouri, Martin Fussenegger (corresponding author)
3 Next generation cell engineering using microRNAsFlorian Klingler, Nadja Raab, Nikolas Zeh, Kerstin Otte (corresponding author)
4 An Omic's data-driven approach towards engineering mammalian cell factories and bioprocesses for biopharmaceutical productionMauro Torres, Veronica Ortuzar, Alan J. Dickson (corresponding author), Hirra Hussain 5 Redesigning spent media from cell culture bioprocess to feed new bacterial fermentations.Ciara Lynch, Lynda Jordan, David O'Connell
6 Monoclonal antibody glycoengineering for biopharmaceutical quality assuranceItzcoatl Gomez Aquino, Ioscani Jimenez del Val (corresponding author)
7 Next-generation cell engineering platform for improving recombinant protein production in mammalian cellsSung Wook Shin, Minji Kyeong, Jae Seong Lee (corresponding author)

Part II: Development of cell-based technologies and therapeutics
8 Manufacturing human pluripotent stem cells and differentiated progenitorsSvetlan Vassilev, Steve Kah Weng Oh (corresponding author)
9 Biomanufacturing of Mesenchymal Stromal Cell for Therapeutic ApplicationsRoss A. Marklein, Morgan Mantay, Cheryl Gomillion, James N. Warnock (corresponding author)
10 Process Design for hMSC Products in Stirred Tank Bioreactors Jan Barekzai, Florian Petry, Peter Czermak, Denise Salzig
11 Bio-production of Adeno-associated virus for gene therapy Nicholas Donohue, Niamh Keogh, Stefano Boi, Niall Barron (corresponding author)
Part III: Cell culture process engineering, advanced bioreactor concepts, modelling, monitoring and control
12 scale-up (and scale-down) of CHO cell culture, with a focus on how to adjust the various culture parameters/setpoints across different systems from lab-scale to manufacturing-scaleLucas Lemire, Phuong Lan Pham, Olivier Henry
13 Intensified and Continuous mAb Production with Single-Use SystemsJan Muller, Misha Teale, Sandra Steiner, Stefan Junne, Peter Neubauer, Dieter Eibl, Regine Eibl (corresponding author)
14 Mathematical modelling of cell culture processesVeronique Chotteau (corresponding author), Erika Hagrot, Liang Zhang, Meeri Makinen
15 Model-assisted design concepts for mammalian cell culture processesJohannes Moeller (corresponding author), Ralf Poertner
16 Bioprocess monitoring and controlJordi Joan Cairo, Marti Lecina (corresponding author)
17 Industrial Monitoring of Cell CultureSebastian Schwamb, Markus Engel, Tobias Werner, Philipp Wiedemann (corresponding author)