Main description:

In front of you is the finished product of your work, the text of your contributions to the 2003 Dayton International Symposium on Cell Volume and Signal Transduction. As we all recall, this symposium brought together the Doyens of Cellular and Molecular Physiology as well as aspiring young investigators and students in this field. It became a memorable event in an illustrious series of International Symposia on Cell Volume and Signaling. This series, started by Professors Vladimir Strbák, Florian Lang and Monte Greer in Smolenice, Slovakia in 1997 and continued by Professors Rolf Kinne, Florian Lang and Frank Wehner in Berlin in 2000, is projected for 2005 in Copenhagen to be hosted by our colleague, Professor Else Hoffmann and her team. We dearly miss Monte Greer to whom this symposium was dedicated and addressed so eloquently by Vladimir Strbák in his Dedication to Monte. Monte and I became friends in Smolenice and had begun to discuss the 2003 meeting only a few days before his tragic accident in 2002. There are others who were not with us, and we missed them, too. We would not have been able to succeed in this event without the unflagging support of our higher administration at Wright State University, the NIDDKD of the National Institute of Health, and the Fuji Medical System (see Acknowledgments).

Feature:

Dr. Lauf has received several awards such as an NIH career award in 1971, the Golding Research Professorship at Wright State in 1988, the 1998 Research Award from the Affiliate Society Council of Engineering in Dayton, OH, and the University Professor Title at Wright State University in 2003

Contributors are leaders in the fields of neurobiology, physiology, biophysics, and cell biology

Contents:

Transport in avian red cells.- The Balancing Act of the Naked Cell.- Electroneutral Cotransporters.- Twenty-Five Years of K-Cl Cotransport: From Stimulation by a Thiol Reaction to Cloning of the Full-Length KCCs.- Molecular Physiology of Mammalian K+-CL? Cotransporters.- STE20 Kinases and Cation-Chloride Cotransporters.- Molecular Physiology of the Renal Na+-Cl? and Na+-K+-2Cl? Cotransporters.- The Role of the Blood-Brain Barrier Na-K-2Cl Cotransporter in Stroke.- Regulation of Na-K-2Cl Cotransport in Red Cells.- A Novel NHE1 from Red Blood Cells of the Winter Flounder.- Ion Channels and Exchangers.- Probing of the ICln Channel Pore by Cysteine Mutagenesis and Cadmium-Block.- Volume-Dependent and -Independent Activated Anion Conductances and Their Interaction in the Renal Inner Medullary Collecting Duct (IMCD).- Secretory Control of Basolateral Membrane Potassium and Chloride Channels in Colonic Crypt Cells.- Effects of Ammonium on Ion Channels and Transporters in Colonic Secretory Cells.- The Volume-Activated Chloride Current Depends on Phospholipase C Activation and Intracellular Calcium Mobilization.- Nitric Oxide (NO) Modulation of Cl-Dependent Transporters in the Kidney.- Volume Activated Anion Channel and Astrocytic Cellular Edema in Traumatic Brain Injury and Stroke.- Cell Volume, Cytoskeleton and Apoptosis.- Effectors and Signaling Events Activated by Cell Shrinkage in Ehrlich Ascites Tumor Cells.- Water Movement During Apoptosis.- Apoptosis and Cell Volume Regulation.- Anion Channel Involved in Induction of Apoptosis and Necrosis.- Erythrocyte Ion Channels in Regulation of Apoptosis.- Apoptosis VS. Oncosis: Role of Cell Volume and Intracellular Monovalent Cations.- Polycystin-2 as a Signal Transducer.- Further Characterization of the Nematode IClnN2 Protein Reconstituted in Lipid Bilayers.- Hypertonicity-Induced Cation Channels in Rat Hepatocytes and Their Intracellular Regulation.- Cell Volume Sensing and Regulation in Skeletal Muscle Cells.- Q-VD-OPh, Next Generation Caspase Inhibitor.- Osmolyte Transporters and Signaling.- Are Membrane Tyrosine Kinase Receptors Involved in Osmotransduction?.- Glial-Neuronal Signaling and Astroglial Swelling in Physiology and Pathology.- Cell Swelling-Induced Peptide Hormone Secretion.- Volume Regulation of the Hippocampus.- Cell Volume Regulation in Intestinal Epithelial Cells.- Regulation of Epithelial Electrolyte Transporters through Protein-Protein Interactions.- The Role of the Phosphoinositide Pathway in Hormonal Regulation of the Epithelial Sodium Channel.- Modulation of Volume-Sensitive Taurine Release from NIH3T3 Mouse Fibroblasts by Reactive Oxygen Species.- Hypertension in K-Cl Cotransporter-3 Knockout Mice.- Abstracts.- Physiology and Pathophysiology of the Erythrocyte Gardos Channel in Hematological Diseases.- Swelling-Activated Calcium-Dependent Potassium Channels In Airway Epithelial Cells.- KCNQ Channels are Sensors of Cell Volume.- Membrane Localization of the Neuronal K-Cl Cotransporter (K-Cl COT, KCC2) in Rat Cerebellum.- K-Cl Cotransport (K-Cl COT, KCC) Activation by N-Ethylmaleimide in C6 Glioma Cells.- Expression of Plasma Membrane Ca2+ ATPase in Crayfish During Molting.- Salinity Affects Crayfish PMCA and NCX Expression.- Crayfish Epithelial Ca2+ Channel-Like Gene (ECaC).- Modulation of KCNQ4 Channels by Changes in Cell Volume.- PKA Phosphorylation of SGK Modulates ADH-Stimulated Na+ Transport in A6 Model Renal Cells.- Cell Volume Modifies an ATP-Sensitive Anion Conductance in Cultured Hippocampal Astrocytes.- ADH-Stimulated Na+ Transport: Interaction between the cAMP/PKA and Phosphoinositide Signaling Pathways.- Effect of Aldosterone on Na+ Transport in a Model Renal Epithelial Cell Line.- Upregulation of NCX Protein in Hepatopancreas and Antennal Gland of Freshwater Crayfish Associated with Elevated CA2+ Flux.