Main description:

A comprehensive survey of the most recent discoveries in this field.

Provides a platform of knowledge that will lead to the development of more effective methods for controlling the spread of RNA viruses or modifying their disease course.
Synthesizes recent findings in this fast-moving field while also reviewing accepted knowledge.
Focuses on the antiviral signaling pathways in the host, including specific pattern recognition receptors and how these cellular alarms signal the innate immune response.
Examines the ways in which specific major RNA virus families interact with, activate, and elude these signaling pathways and responses.

This title is published by the American Society of Microbiology Press and distributed by Taylor and Francis in rest of world territories.

Contents:

Table of Contents

I. Introduction

1.Introduction and Overview, Allan R. Brasier, Adolfo Garcia-Sastre, and Stanley M. Lemon

II. Antiviral Signaling Pathways and Their Contributions to Virus Control and Pathogenesis

2.Role of Toll-Like Receptors in the Innate Immune Response to RNA Viruses, Sinead E. Keating and Andrew G. Bowie

3. Cytoplasmic Pattern Receptors and Signaling in Viral Infections, Osamu Takeuchi and Shizuo Akira

4. Mitochondrial Antiviral Signaling, Vijay G. Bhoj and Zhijian J. Chen

5. Interferon Regulatory Factors and the Atypical IKK-Related Kinases TBK1 and IKK[e]: Essential Players in the Innate Immune Response to RNA Virus Infection, Meztli Arguello, Suzanne Paz, and John Hiscott

6. Jak-Stat Pathway in Response to Virus Infection, Joan E. Durbin

7. Interferons and Antiviral Action, Christine L. White and Ganes C. Sen

8. The Nuclear Factor-[k]B Transcription Factor Pathway, Amer A. Beg and Xingyu Wang

9. The Nuclear Factor-[k]B Signaling Network: Insights from Systems Approaches, Allan R. Brasier

10. Type I Interferon Signaling in Shaping Cellular Innate and Adaptive Immunity to Viral Infection, Christine A. Biron

11. Biological Impact of Type I Interferon Induction Pathways beyond Their Antivirus Activity, Bahram Razani, Arash Shahangian, Beichu Guo, and Genhong Cheng

12. Human Genetic Factors Involved in Viral Pathogenesis, Lennart Svensson and Elin Kindberg

III. Activation and Evasion of Host Antiviral Signaling Pathways by RNA Viruses

13. RNA Virus Families: Distinguishing Characteristics, Differences, and Similarities, Peter W. Mason and Frank Scholle

14. Rhabdoviruses and Mechanisms of Type I Interferon Antagonism, Krzysztof Brzozka and Karl-Klaus Conzelmann

15. Filoviruses, Christopher F. Basler

16. Inhibition of Antiviral Signaling Pathways by Paramyxovirus Proteins, Antonella Casola, Xiaoyong Bao, Allan R. Brasier, and Roberto P. Garofalo

17. Suppression of Innate Immunity by Orthomyxoviruses, Randy A. Albrecht and Adolfo Garcia-Sastre

18. Bunyaviruses and Innate Immunity, Friedemann Weber and Richard M. Elliott

19. Arenaviruses, Juan C. de la Torre

20. Regulation of Innate Immunity by the Flaviviridae, Brenda L. Fredericksen and Michael Gale, Jr.

21. Evasion of Innate Host Antiviral Defenses by Picornaviruses, Stanley M. Lemon

22. Togaviruses, William B. Klimstra and Kate D. Ryman

23. Coronaviruses and Arteriviruses, Krishna Narayanan and Shinji Makino

24. Caliciviridae and Astroviridae, Susana Guix and Mary K. Estes

25. Innate Immune Responses Elicited by Reovirus and Rotavirus, Barbara Sherry, John T. Patton, and Terence S. Dermody

IV. Summary and Perspectives

26. Summary and Perspectives, Allan R. Brasier, Adolfo Garcia-Sastre, and Stanley M. Lemon