Main description:

Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomics focuses on critical issues in therapeutic drug monitoring including special requirements of therapeutic drug monitoring important to special populations (infants and children, pregnant women, elderly patients, and obese patients). The book also covers issues of free drug monitoring and common interferences in using immunoassays for therapeutic drug monitoring.

This book is essential reading for any clinician, fellow, or trainee who wants to gain greater insight into the process of therapeutic drug monitoring for individual dosage adjustment and avoiding drug toxicity for certain drugs within a narrow therapeutic window. The book is written specifically for busy clinicians, fellows, and trainees who order therapeutic drug monitoring and need to get more familiar with testing methodologies, issues of interferences, and interpretation of results in certain patient populations.

Contents:

Overview of Therapeutic Drug Monitoring

Immunoassays and Issues with Interference in Therapeutic Drug Monitoring

Application of Chromatography Combined with Mass Spectrometry in Therapeutic Drug Monitoring

Clinical Utility of Free Drug Monitoring

Therapeutic Drug Monitoring of Newer Antiepileptic Drugs

Therapeutic Drug Monitoring of Antiretrovirals

Therapeutic Drug Monitoring in Infants and Children

Therapeutic Drug Monitoring in Pregnancy

Therapeutic Drug Monitoring in the Elderly

Therapeutic Drug Monitoring in Obese Patients

Special Issues in Therapeutic Drug Monitoring in Patients with Uremia, Liver Disease, and Critically Ill Patients

Integrating Therapuetic Drug Monitoring and Pharmacogenomics

Warfarin Pharmacogenomics

Drug Monitoring in Alternative Matrices

Integrating and Supporting Therapeutic Drug Monitoring in a Hospital System