Main description:

This book provides a state-of-the-art overview of acute lymphoblastic leukemia (ALL). The first section of the book presents the translational science behind ALL, reviewing molecular pathways and targets in B- and T-cell ALL, as well as techniques and application of minimal residual disease testing. The second section spotlights ALL management strategies for patients across the spectrum, from infants to the elderly. The final section outlines current and new advances in ALL treatment, including new monoclonal antibodies and allogenic and autologous HSCT.
Written by experts in the field, Clinical Management of Acute Lymphoblastic Leukemia: From Bench to Bedside is a valuable resource that will guide patient management, stimulate investigative efforts, and increase understanding of the biologic underpinnings of the disease.

Contents:

I - TRANSLATIONAL SCIENCE

1. Molecular pathways and targets in B cell progenitor acute lymphoblastic leukemia

2. Genetic Mechanisms in T-Cell Acute Lymphoblastic Leukemia

3. Minimal Residual Disease in Acute Lymphoblastic Leukemia - Techniques and Application

II - THERAPEUTICS

4. Treatment of Pediatric B and T cell ALL

5. Treatment of Adult B and T cell Acute Lymphoblastic Leukemia: An Overview of Current Treatments and Novel Advances

6. Acute Lymphoblastic Leukemia in Infants: A distinctive, high risk subtype of childhood ALL

7. Treatment of Elderly Patients with Acute Lymphoblastic Leukemia

8. Treatment of Childhood Philadelphia-Chromosome Positive Acute Lymphoblastic Leukemia

9. Treatment of adult Philadelphia chromosome positive ALL

10. Treatment of Ph-like ALL

11. Prophylaxis and treatment of central nervous system (CNS) ALL

12. Late effects of therapy of acute lymphoblastic leukemia

III - NEW AND EXISTING MODALITIES OF THERAPY

13. Monoclonal Antibody Based Treatment and Other New Agents for B-Lineage ALL

14. New Agents for the Treatment of T-Cell ALL

15. The development and management of treatment with chimeric-antigen receptor T cell (CAR-T)

16. Hematopoietic Stem Cell Transplantation in Adults with Acute Lymphoblastic Leukemia (ALL)

17. Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia