Main description:

The authors present the most current and cutting-edge knowledge regarding the molecular basis of cerebellar development, focusing on information relevant to laboratory scientists and clinicians providing service to patients with cerebellar disorders. Knowledge obtained from advanced neuroimaging techniques that are used during development, and from molecular- and genetic-based studies has provided rapidly-growing evidence that the cerebellum is a brain region that is highly impacted by developmental defects. Cerebellar defects result in significant intellectual and motor function impairment that affects both the patients and their families.

Contents:

1) A historical overview of cerebellar neurodevelopmental disorders; V. Persaud, U of Manitoba, Canada
2) Epidemiology of cerebellar disorders; S. Shooshtari, U of Manitoba, Canada
3) Cerebellar embryology, anatomy, and function; H. Bergen, U of Manitoba, Canada
4) Developmental patterns in the cytoarchitecture of the cerebellum; R. Hawkes, U of Calgary, Canada
5) Developmental disorders of the cerebellum; M. Del Bigio, U of Manitoba, Canada
6) Developmental disorders of the cerebellum and GABAergic signaling pathway; G.G. Consalez, San Raffaele Scientific Institute, Italy
7) Developmental disorders of the cerebellum and glutamatergic signaling pathway; S. Ying, Hangzhou University, China
8) Developmental disorders of the cerebellum and cerebellar nuclei neurons; R. Hevner, Seattle Children's Research Institute, USA
9) Developmental disorders of the cerebellum and nerve growth factor signaling pathway; S. Chung, U of Illinois, Chicago, USA
10) Developmental disorders of the cerebellum and glial cells; J. Kong, U of Manitoba, Canada
11) Developmental disorders of the cerebellum and genetics; A. Joyner, New York Memorial Hospital, USA
12) Developmental disorders of the cerebellar afferent and efferent (ataxia); R. Sillitoe, Baylor College of Medicine, USA
13) Developmental disorders of the cerebellum and fetal alcohol syndrome; A. Chudley, U of Manitoba, Canada
14) Developmental disorders of the cerebellum and autism spectrum disorder; H. Fatemi, University of Minnesota Medical School, USA
15) Developmental disorders of the cerebellum and immune system malfunction; A.A. Owji, Shiraz University of Medical Sciences, Iran<
16) Developmental disorders of the cerebellum and Apoptosis, Autophagy, UPR; S. Ghavami, U of Manitoba, Canada
17) Developmental disorders of the cerebellum and ubiquitin proteasome system; J. Vriend, U of Manitoba, Canada
18) Developmental disorders of the cerebellum and mitochondrial damages; M.J. Hosseini, Zanjan University of Medical Sciences, Iran.
19) Developmental disorders of the cerebellum and tumors; T. Klonisch, U of Manitoba, Canada
20) Developmental disorders of the cerebellum and teratogen, toxin, and radiation; A. Chudley, and V Persaud, U of Manitoba, Canada
21) Developmental disorders of the cerebellum and endocrine diseases; N. Koibuchi, Gunma University, Japan
22) Developmental disorders of the cerebellum and infectious diseases; K. Coombs, U of Manitoba, Canada
23) Animal models for the study of developmental disorders of the cerebellum; D. Goldowitz, U of British Columbia, Canada
24) Neuroimaging and cerebellar disorder; K.J. Millen, Seattle Children's Hospital, USA
25) Diagnosis, Clinical Symptoms,