Main description:

Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing, Second Edition assembles a group of experts to discuss the molecular basis and mechanisms of major human diseases and disease processes and how the molecular features of disease can be harnessed to develop practical molecular tests for disease detection, diagnosis and prognosis. The book explains how molecular tests are utilized in the treatment of patients in personalized medicine, highlights new technologies and approaches of applied molecular pathology, and discusses how this discovery-based research yields new and useful biomarkers and tests.

As it is essential to stay up-to-date on new molecular diagnostics in this changing field, this book covers critically important areas in the practice of personalized medicine and reflects our understanding of the pathology, pathogenesis and pathophysiology of human disease.

Contents:

Section I: Introduction to Molecular Testing
1. Basic Concepts in Molecular Pathology-Introduction to Molecular Testing in Human Disease
2. Laboratory Approaches in Molecular Pathology-The Polymerase Chain Reaction
3. Next-Generation Sequencing in the Clinical Laboratory
4. Automation of the Molecular Diagnostic Laboratory

Section II: Molecular Testing in Infectious Disease
5. Molecular Testing for Human Imunodeficiency Virus
6. Molecular Testing in Hepatitis Virus Related Disease
7. Molecular Testing for Human Papillomaviruses
8. Molecular Testing for Herpes Viruses
9. Molecular Testing for Parvoviruses
10. Molecular Testing for Polyomaviruses
11. Molecular Testing for Respiratory Viruses
12. Molecular Testing for Diseases Associated with Bacterial Infections
13. Agents Associated with Sexually Transmitted Infections
14. Molecular Methods for Healthcare-Acquired Infections
15. Molecular Testing in Emerging Infectious Diseases

Section III: Molecular Testing in Genetic Disease
16. Noninvasive Prenatal Screening (NIPS) for Fetal Aneuploidies
17. Molecular Testing in Inherited Cardiomyopathies
18. Molecular Diagnostics for Coagulopathies
19. Molecular Diagnosis of Cystic Fibrosis
20. Molecular Testing in Hemochromatosis

Section IV: Molecular Testing in Oncology
21. Molecular Testing in Breast Cancer
22. Molecular Pathology of Prostate Cancer
23. Molecular Testing in Lung Cancer
24. Molecular Testing in Colorectal Cancer
25. Molecular Pathology and Testing in Melanocytic Tumors
26. Molecular Testing for Glioblastoma
27. Molecular Testing in Pancreatic Cancer
28. Molecular Testing in Gynecologic Cancer
29. The Emerging Genetic Landscape in Renal Cell Carcinoma
30. Molecular Testing in Thyroid Cancer
31. Molecular Testing in Pediatric Cancers

Section V: Molecular Testing in Hematopathology
32. Molecular Testing in Chronic Myelogenous Leukemia
33. Molecular Testing in Acute Myeloid Leukemia
34. Molecular Testing in Myeloproliferative Neoplasms
35. Molecular Testing in the Assessment of Bone Marrow Transplant Engraftment

Section VI: Molecular Testing in Personalized Medicine
36. Personalized Medicine in Cardiovascular Disease
37. Personalized Medicine for Coagulopathies
38. Personalized Medicine for Hepatitis C Virus
39. Personalized Medicine in Cancer Treatment

Section VII: The Future of Molecular Testing
40. Imaging Mass Spectrometry in Clinical Pathology
41. Whole Genome Sequencing in the Molecular Pathology Laboratory