Main description:

Cutaneous adverse drug reactions are common and range from the benign to those which are life-threatening. The clinical presentation of these dermatoses is varied and many may mimic common skin conditions. Consequently, diagnosis in drug-induced skin disease is challenging and the treatment considerations are complex. This book aims to bridge the divide between dermatology and allergy by providing a comprehensive review on the pathomechanisms and clinical features of cutaneous adverse drug reactions. Broken up into three distinct sections: General Considerations, Reaction Patterns, and Special Drug Categories, these chapters cover the common and rare adverse skin reactions and provide information on recent advances - particularly immunopathology and pharmacogenetics - as well as highlighting new adverse drug signals and novel therapies. Drug Eruptions is a must-have resource for dermatologists, allergists, internal physicians and general practitioners.

Contents:

Section 1 : General Considerations* Epidemiology of Drug Hypersensitivity* Mechanisms of Drug Hypersensitivity* Histopathologic patterns of Drug Eruptions* Clinical Approach to a Patient with Drug Hypersensitivity Reactions* Skin Tests in evaluating Drug EruptionsSection 2: Reaction Patterns* Drug-induced urticaria, angioedema and anaphylaxis* Exanthematous Drug Eruptions* Stevens-Johnson syndrome / Toxic Epidermal Necrolysis* Acute Generalized Exanthematous Pustulosis* Drug Reaction Eosinophilia and Systemic Symptoms* Fixed Drug Reactions and Generalized Bullous Fixed Drug Eruptions* Lichenoid skin eruptions* Drug-induced lupus erythematosus and other connective tissue diseases* Drug-induced vasculitis * Drug-induced autoimmune blistering dermatoses.* Other drug-induced inflammatory skin reactions* Drug-induced photosensitivity* Drug-induced pruritus* Drug induced nail changes* Drug induced hair changes* Drug induced pigmentary changesSection 3: Special Drug Categories* Immediate and Delayed reactions to Beta-lactams* Immediate and Delayed reactions to Radiocontrast Media * Cutaneous adverse reactions to biologicals * Cutaneous reactions to Oncologic Targeted therapy * Cutaneous reactions to Oncologic Targeted Immunotherapy