Main description:

This book discusses the current state of knowledge about potential drug targets against malaria. It reviews the current drug targets and focuses on the progress made on the latest scientific and technological advances in discovering and developing novel antimalarial agents. The initial chapter discusses the existing antimalarial agent, including quinoline derivatives, an antifolate, and artemisinin derivatives. It further explores the potential of Plasmodium kinases as drug targets for the treatment of malaria. Notable, the book examines the major metabolic pathways of the parasite that are explored as novel sites for drug design, including heme detoxification, fatty acid synthesis, nucleic acid synthesis, fatty acid synthesis, and oxidative stress. This volume also presents antineoplastic chemotherapy that targets DNA replication and other cancer agents against the malaria parasites with possible off-target action. Lastly, it discusses Plasmodium proteases, a suitable multistage target for designing novel drugs with new modes of action to combat malaria.

Contents:

Chapter 1_Existing antimalarial drugs. - Chapter 2_Novel Antimalarial Targets. - Chapter 2.1_Parasite Proteases. - Chapter 2.2_Protein kinases. - Chapter 2.3_Transporters as potential drug targets. - Chapter 2.3.1_Plasmodium Sugar Transporter. - Chapter 2.3.2_Lactate Transporter. - Chapter 2.3.3_P-Type Na+ATPase. - Chapter 2.3.4_V-Type H +-ATPase. - Chapter 2.3.5_Aquaporin-3. - Chapter 2.3.6_Choline Transport. - Chapter 2.3.7_Dihydroorotate Dehydrogenase. - Chapter 2.4_Isoprenoid Biosynthesis. - Chapter 2.4.1_Farnesyltransferase. - Chapter 2.5_DNA Targets. - Chapter 2.6_P. falciparum Translational Elongation Factor 2. - Chapter 2.7_Anti-Adhesive Polysaccharide. - Chapter 2.8_Metabolic enzymes as potential drug targets. - Chapter 2.9_Heast shock proteins as targets for novel antimalarial drugs.