Main description:

Cutting-edge engineering approaches towards modelling lung homeostasis and disease have created dynamic new opportunities for interdisciplinary collaboration and unprecedented progress toward understanding and treating lung disease. This text connects established research in lung biology and physiology to innovative engineering strategies for pulmonary modelling. This unique approach aims to encourage and facilitate progress among a greater audience of basic and translational scientists, clinicians, and medical practitioners.

Engineering Translational Models of Lung Homeostasis and Disease illustrates the advances in lung tissue characterization, revealing dynamic changes in the structure, mechanics, and composition of the extracellular matrix. This information paves the way for tissue-informed engineering models of pulmonary tissue, improved design of clinical materials, and advances against a variety of common pathologies. Current translational challenges are highlighted, as are engineering opportunities to overcome these barriers. This foundational text holds valuable lessons for researchers and clinicians throughout the fields of engineering, materials science, cell biology, pulmonary medicine, and clinical science.

* Each section focuses on a specific region of the lung, presenting either the biological or clinical perspective along with complimentary engineering approaches

* Covers the interface of engineering and lung biology

* Highlights emerging new models to study lung disease and repair

Contents:

Introduction to the book (Darcy and Chelsea)

Section I: Vasculature

Translator: Laura Niklason, Yale University
Engineering I: Jordan Miller, Rice University
Engineering II: Peter Chan, Wei Tan, University of Colorado at Denver

Section II: Alveoli

Translator: Jason Spence, University of Michigan
Engineering I: Darcy Wagner, Lund University

Engineering II: Olivier Guenat, University of Bern

Section III: Fibroblasts

Translator: Daniel Tschumperlin, Mayo Clinic
Engineering I: Janette Burgess, University of Groningen
Engineering II: Chelsea Magin, University of Colorado

Section IV: Airways

Translator: Sam Janes, University College London, Scott Randell, University North Carolina, Martin Birchall, University College London
Engineering I: Adam Feinberg, Carnegie Mellon University
Engineering II: Don Ingber, Harvard University/Sarah Gilpin, Massachusetts General Hospital

Section V: Engineering the clinical interface between medical materials and the lung

13. Translator: Sandra Lindstedt (ECMO, EVLP, endobronchial valves, sealants, stents), Lund University

14. Engineering: Sinem Tas, Lund University

Concluding (lymph, nervous/innervation, immune)